目的 探讨感染高危型人乳头瘤病毒(HPV)的临床特点。方法 选择2013-01至2021-12北京京煤集团总医院行HPV分子检测中HPV16阳性患者542例,分析患者合并感染其他HPV情况、不同年龄段感染情况及HPV16转阴情况。结果 (1)542例中,单一阳性330例,占60.9%;合并其他高危感染173例,占31.9%;合并低危感染39例,占7.2%;合并其他高危组宫颈活检CIN Ⅱ及以上患病率(44.2%)高于合并低危组(21.4%,χ2=4.880,P=0.027)。(2)≤29岁、30～39岁、40～49岁、50～59岁、≥60岁各年龄组患者三种感染情况的总体分布差异无统计学意义(χ2=11.185,P=0.191);≤29岁年龄组与30～49岁年龄组相比宫颈活检构成比差异无统计学意义(χ2=3.369,P=0.338);30～49年龄组宫颈鳞状上皮内病变CIN Ⅲ级检出率高于其他年龄组(χ2=4.566,P=0.033);50岁以下组上皮内瘤变检出率更高(χ2=10.313,P<0.001)。(3) 183例随诊中,134例HPV16转阴,转阴时间2～75个月,中位数16个月;359例宫颈活检患者,随诊152例HPV16转阴,转阴时间1～39个月,中位数8个月,差异有统计学意义(U=6681,P＜0.0001)。结论 对年龄小于50岁,且合并其他高危型感染的HPV16感染患者,应积极行阴道镜活组织病理检查。
Abstract
Objective To probe the clinical characteristics of patients with high-risk human papillomavirus of human papilloma virus (HPV)16 infection. Methods A total of 542 patients who were positive for HPV in HPV molecular test were selected from Beijing Jingmei Group General Hospital from January 2013 to December 2021. The patients were analyzed for co-infection with other HPV, infection in different age groups and negative conversion of HPV16. Results Of the 542 patients, 330(60.9%) were single positive, 173(31.9%) were complicated with other high-risk infections, and 39(7.2%) were complicated with low-risk infections The prevalence rate of CIN II and above in cervical biopsy with other high risk group (44.2%) was higher than that in cervical biopsy with low risk group (21.4%),(χ2=4.880, P=0.027) . There was no significant difference in the overall distribution of the three types of infection among the age groups ≤29,30-39,40-49,50-59 and ≥60,(χ2=11.185, P=0.191) . There was no significant difference in the constituent ratio of cervical biopsy between ≤29-year-old group and 30-49-year-old group (χ2=3.369, P=0.338) .The detection rate of CIN III in 30-49 age group was higher than that in other age groups (χ2=4.566, P=0.033), and the detection rate of CIN was higher in under 50 age group (χ2=10.313,P<0.001). Among the 183 follow-up patients, 134 cases turned negative for HPV16, with a median time of 16 months (2-75 months), and 152 cases turned negative for HPV16, with a median time of 1-39 months (1-39 months), the median was 8 months(U=6681,P＜0.0001). Conclusions Clinically, colposcopic biopsy should be performed actively for patients with HPV16 infection who are less than 50 years old and complicated with other high-risk infections.
关键词
HPV16感染 /
合并感染 /
转阴时间 /
阴道镜活组织病理检查
Key words
HPV16 infection /
coinfection /
turning negative time /
colposcopy biopsy
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