目的 观察α1b干扰素局部注射联合液氮冷冻治疗多发性跖疣的临床疗效。方法 选择2019-10至2021-02在武警特色医学中心皮肤科就诊的83例多发性跖疣患者,随机分为观察组和对照组,观察组42例选择α1b干扰素局部注射联合液氮冷冻方法治疗,每2周治疗1次,连续治疗8周;对照组41例采用液氮冷冻治疗,治疗方法及治疗时间与对照组相同。疗程结束后两组均随访6个月,比较两组疗效、疼痛耐受指标、复发率和不良反应发生情况。结果 将退出试验的4例(4.82%)病例数据剔除,共79例患者完成试验。观察组总有效率为89.74%,高于对照组的82.50%,差异有统计学意义(P<0.05);观察组有3例因疼痛不耐受退出试验,对照组有1例,对照组治疗疼痛耐受优于观察组;6个月后,观察组复发率为15.38%,对照组复发率为35.00%(P<0.05);两组不良反应发生率差异无统计学意义,但症状分布不同,观察组主要在于疼痛,对照组在于感染和水疱血疱,两组均无严重不良反应。结论 α1b干扰素局部注射联合液氮冷冻治疗多发性跖疣疗效优于单用液氮冷冻治疗,且复发率低,对于疼痛耐受患者尤为适用。

Objective To observe the efficacy of local injection of recombinant human interferon α1b combined with liquid nitrogen cryotherapy for multiple plantar warts. Methods Eighty-three patients with multiple plantar warts from October 2019 to February 2021 were randomly divided into observation group (42 patients) and control group (41 patients) according to the random method. The patients in the observation group were treated with local injection of α1b interferon combined with liquid nitrogen freezing method, once every 2 weeks, and continued treatment for 8 weeks, while the patients in the control group were treated with liquid nitrogen cryotherapy and the treatment method and treatment time were the same as those in the control group. After the end of the course of treatment, both groups were followed up for 6 months, and the efficacy, pain tolerance index, recurrence rate and adverse reactions were observed and compared. Results Data from 4 cases (4.82%) who withdrew from the trial were excluded, and a total of 79 patients completed the trial. The total effective rate of the observation group was 89.74%, higher than that of the control group of 82.50% (P<0.05); 3 cases of the observation group withdrew from the trial due to pain intolerance, and 1 case form the control group, the pain tolerance of the control group was better than the observation group; after 6 months, the recurrence rate of the observation group was 15.38%, which was lower than 35.00% of the control group (P<0.05), there was no statistical difference in adverse reactions between the two groups, but the distribution of symptoms was different, the main symptom of the observation group was pain, while the main symptoms were infection and blisters in the control group, and there were no serious adverse reactions in both groups. Conclusions Local injection of α1b interferon combined with cryotherapy for multiple plantar warts is more effective than cryotherapy with liquid nitrogen alone, with low recurrence rate, especially for pain-tolerant patients.