目的 探讨药师参与门诊对儿童喘息性支气管炎的治疗效果。方法 选取2020-01至2021-12在武警江西总队医院就诊的200例喘息性支气管炎患儿,随机分为干预组和对照组,每组100例。干预组通过联合门诊综合干预,严格把控住院指征及抗菌药物使用,选择合适的吸入剂型,进行个体化用药指导,对照组采取常规治疗方法。对比两组患儿喘息缓解时间,肺功能指标第1秒用力呼气量(FEV1)、用力肺活量(FVC)、第1秒用力呼气量与用力肺活量比值(FEV1/FVC)及治疗费用。两组患儿随访时间为1年,对比再次发作及再次入院次数。结果 治疗后,干预组喘息缓解时间显著短于对照组[(39.90±8.76)h vs. (61.55±11.66)h],FEV1/FVC改善情况优于对照组[(94.52±1.75)% vs. (85.84±4.73)%],差异均有统计学意义(P<0.05)。干预组与对照组比较,住院率、抗菌药物使用率、治疗费用、1年内再次发作喘息次数及住院次数差异均有统计学意义(P<0.05)。结论 通过药师参与门诊的干预,可明显提升儿童喘息性支气管炎的治疗效果,降低复发率,减少治疗费用。
Abstract
Objective To explore the effect of pharmacists participating in outpatient treatment of children with asthmatic bronchitis. Methods Two hundred children patients with asthmatic bronchitis who were recruited from January 2020 to December 2021 from the Jiangxi Provincial Corps Hospital of Chinese People’s Armed Police Force were randomly divided into the intervention group and control group, with 100 cases in each group. The intervention group accepted joint outpatient comprehensive intervention, including strict control of the hospitalization indications and the use of antibiotics, appropriate inhalation dosage forms, and individualized medication guidance. The control group received routine treatment. The wheezing relief time, treatment cost and the pulmonary function of the two groups of children were compared. The pulmonary function indexes included forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC. The two groups were followed up for one year. Results After treatment, the relief time of wheezing in the intervention group was significantly shorter than that in the control group [(39.90±8.76) vs (61.55±11.66)h, P<0.05], and the improvement of FEV1/FVC was better than that in the control group (94.52%±1.75% vs 85.84%±4.73%, P<0.05). The hospitalization rate, the use rate of antibiotics, the treatment cost, and the number of wheezes and hospitalizations within one year in the intervention group were significantly better than those in the control group (P<0.05). Conclusions Through the participation of pharmacists in outpatient intervention, the therapeutic effect of asthmatic bronchitis in children can be significantly improved, and the recurrence rate and the treatment cost can both be reduced.
关键词
药师门诊 /
联合门诊 /
喘息性支气管炎 /
治疗费用 /
循证药学
Key words
pharmacist clinic /
joint outpatient department /
asthmatic bronchitis /
treatment cost /
evidence-based pharmacy
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基金
江西省卫健委科技计划项目(202211395)
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