目的 探讨血清维生素D水平与桥本氏甲状腺炎(hashimoto’s thyroiditis,HT)的关系。方法 选取2021-10至2022-05在武警安徽总队医院就诊的HT患者160例作为病例组,其中男38例,女122例,同时选取医院体检中心健康体检者160例作为对照组,其中男43例,女117例。收集两组患者的年龄、性别、体重指数(BMI)、吸烟史相关资料及促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)、游离甲状腺素(FT4),甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、25羟维生素D[25(OH)D]数据。病例组再分3组:就诊时甲功正常组(HT1组),就诊时甲功异常组(包括甲减、亚临床甲减、甲亢、亚临床甲亢)(HT2组),以及已接受左甲状腺素或抗甲状腺药物治疗组(无论目前甲功是否正常)(HT3组)。结果 病例组25(OH)D水平较对照组均明显降低。对照组25(OH)D的缺乏率为47.68%,病例组维生素D缺乏率均较对照组高(分别为65.42%、69.15%、72.64%),差异均有统计学意义。Logistic回归分析显示,25(OH)D与HT患者的T3、FT3、T4、FT4无明显相关性,与HT2组和HT3组的TSH呈弱负相关,与所有病例组的TPOAb、TGAb呈明显负相关。结论 低维生素D水平与HT的发生发展相关。
Abstract
Objective To investigate the relationship between vitamin D and Hashimoto's thyroiditis (HT) .Methods From October 2011 to May 2022, 160 patients with HT including 38 males and 122 females were selected from Anhui Provincial Corps Hospital of Chinese People’s Armed Police Force, and at the same time, 160 healthy control subjects (43 males and 117 females) were selected from the physical examination center of the same hospital. General information of age, sex, BMI, smoking history and thyroid hormone (TSH, T3, T4, FT3, FT4), TPOAb, TGAb, 25(OH) D levels were collected. The 160 HT patients were further divided into three groups, normal thyroid function group, abnormal thyroid function group, and left thyroid or antithyroid agent treatment group (whether the current thyroid function was normal or not).Results The levels of 25(OH) D in the three groups were significantly lower than those in the control group. The deficiency rate of 25(OH) D in the control group was 47.68%, while the deficiency rates of vitamin D in the three groups were higher than that in the control group (65.42%, 69.15%, 72.64% respectively). Logistic regression analysis showed that 25(OH) D had no significant correlation with T3, T4, FT3, FT4 in HT patients, but had weak negative correlation with TSH in abnormal thyroid function group and treated group, and had significant negative correlation with TpoAb, TgAb in three groups.Conclusions Low level of vitamin D may play a role in the occurrence and development of HT.
关键词
维生素D /
桥本氏甲状腺炎 /
自身免疫性甲状腺疾病
Key words
vitamin D /
Hashimoto’s thyroiditis /
autoimmune thyroid disease
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