目的 评价富血小板纤维蛋白(PRF)对糖耐量受损患者牙槽骨垂直型骨吸收的疗效。方法 选取2019-01至2021-12于北京市昌平区中西医结合医院口腔科就诊的糖耐量异常的慢性牙周炎患者60例,随机分为对照组(n=30)和富血小板血浆治疗组(PRF,n=30)。牙周手术当天和术后6个月,分别检测患者血清中炎性因子白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平,测定出血指数(BI),探诊深度(PD)和附着丧失(AL)的变化,测定骨缺损区骨密度(BMD)和牙槽骨高度的变化。结果 牙周术后6个月,与对照组相比,PRF干预显著降低血清IL-6[(4.01±0.90)ng/L vs.(3.12±1.12)ng/L]和TNF-α浓度[(4.16±1.21)ng/L vs.(3.08±1.32)ng/L](P＜0.05);降低PD[(4.9±1.1)mm vs.(3.1±1.2)mm]和AL[(5.4±1.4)mm vs.(4.2±0.9)mm],差异有统计学意义(P＜0.05)。结论 PRF干预能降低糖耐量受损牙周炎患者血浆炎性因子水平,促进牙周软组织再生。
Abstract
Objective To investigate the effects of platelet-rich fibrin (PRF) on periodontal vertical alveolar bone resorption in patients with impaired glucose tolerance.Methods Sixty patients with chronic periodontitis with abnormal glucose tolerance were selected and randomly divided into control (n=30) and PRF (n=30) groups. On the day of periodontal surgery and 6 months after surgery, the serum levels of inflammatory factor interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α), bleeding index (BI), probing depth (PD), attachment loss (AL), bone mean density (BMD) and the height of alveolar in defect zone were determined.Results Six months after periodontal surgery, compared with the control group, IL-6 and TNF-α levels in serum, PD and AL all decreased in the PRF group (P＜0.05).Conclusions PRF intervention can reduce inflammatory factor levels in serum and promote periodontal soft tissue regeneration.
关键词
富血小板纤维蛋白 /
糖耐量受损 /
慢性牙周炎 /
炎性因子
Key words
platelet-rich fibrin /
impaired glucose tolerance /
chronic periodontitis /
inflammatory factors
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基金
中国博士后科学基金资助项目(2018M633722)
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