TMCO1在泛癌中的表达模式及其与预后、免疫浸润的相关性分析

董媛; 李佳璐; 王宇; 张晓莉

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武警医学 ›› 2023, Vol. 34 ›› Issue (9) : 771-780.

论著

TMCO1在泛癌中的表达模式及其与预后、免疫浸润的相关性分析

董媛^1,2, 李佳璐^1,2, 王宇³, 张晓莉²

作者信息 +

Expression pattern of TMCO1 in pan-cancer and its correlation with prognosis and immune invasion

DONG Yuan^1,2, LI Jialu^1,2, WANG Yu³, ZHANG Xiaoli²

Author information +

文章历史 +

摘要

目的探究跨膜和螺旋结构域1(TMCO1)在泛癌中的表达水平及与其预后、免疫浸润的关系。方法使用GEPIA数据库、TIMER2.0数据库分析泛癌TMCO1基因表达量,使用GEPIA、UCSC数据库分析TMCO1与预后指标相关性,sangerbox数据库及TIMER2.0分析TMCO1表达与免疫细胞浸润及免疫检查点基因表达相关性,最后使用String和GEPIA数据库获取肿瘤中与TMCO1结合或共表达的基因,进行GO和KEGG富集分析。结果与正常组织相比,TMCO1在多数肿瘤中表达水平上调,少数肿瘤中下调。TMCO1高表达与6种肿瘤较差预后相关,与1种肿瘤预后较好有关。TMCO1与中性粒细胞浸润及免疫检查点基因表达有正相关性。富集分析显示TMCO1可能与内质网应激有关。结论 TMCO1是一种与多种肿瘤预后相关的蛋白,其与中性粒细胞浸润、免疫检查点基因表达和内质网应激过程相关,可能成为未来潜在的肿瘤治疗靶点。

Abstract

Objective To investigate the TMCO1 expression levels in pan-cancer and its correlations with prognosis and immune invasion.Methods GEPIA database and TIMER2.0 database were used to analyze the expression levels of TMCO1 in different cancer tissues and adjacent tissues, as well as correlations between TMCO1 expression and the main clinical stages. UCSC database and GEPIA database were used to analyze the prognostic value of TMCO1. Sangerbox database and TIMER2.0 were used to analyze the correlation between TMCO1 and immune cell infiltration and immune checkpoints. Finally, String and GEPIA databases were used to obtain the genes bound or co-expressed with TMCO1 in tumors for GO and KEGG enrichment analysis.Results Compared with normal tissues, the expression of TMCO1 was up-regulated in most tumors and down-regulated in a few tumors. High expression of TMCO1 was associated with poor prognosis of 6 tumors and better prognosis of 1 tumor. TMCO1 was positively correlated with neutrophil infiltration and immune checkpoint gene expression. Enrichment analysis showed that TMCO1 might be related with endoplasmic reticulum stress.Conclusions TMCO1 is a protein associated with the prognosis of various tumors, which is related with neutrophil infiltration, immune checkpoint gene expression and endoplasmic reticulum stress process, and may be a potential tumor therapeutic target in the future.

导出引用

董媛, 李佳璐, 王宇, 张晓莉. TMCO1在泛癌中的表达模式及其与预后、免疫浸润的相关性分析[J]. 武警医学. 2023, 34(9): 771-780

DONG Yuan, LI Jialu, WANG Yu, ZHANG Xiaoli. Expression pattern of TMCO1 in pan-cancer and its correlation with prognosis and immune invasion[J]. Medical Journal of the Chinese People Armed Police Forces. 2023, 34(9): 771-780

中图分类号： R730.231

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