目的 探讨正念训练对慢性失眠障碍患者治疗效果及炎症因子的影响。方法 选择82例于2022-02至2023-05在武警吉林总队医院,诊断为慢性失眠障碍(CID)患者,分为观察组和对照组,每组41例。对照组患者口服右佐匹克隆片,观察组患者在右佐匹克隆片基础上结合正念训练治疗。治疗周期均为5周。对两组的总有效率、治疗前后匹兹堡睡眠指数(PSQI)和失眠严重指数(ISI)变化、抑郁焦虑状态和炎症因子变化进行比较。结果 观察组总有效率(90.24%)高于对照组(70.73%),差异具有统计学意义(χ2=4.970,P=0.026)。两组PSQI和ISI量表的评分比较,治疗后均低于治疗前(P＜0.05);观察组治疗后两个量表评分低于对照组(P＜0.05)。两组汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)的评分比较,治疗后低于治疗前(P＜0.05);观察组治疗后两个量表评分低于对照组(P＜0.05)。两组治疗后血清白介素(IL)-1β和肿瘤坏死因子(TNF)-α水平低于治疗前(P＜0.05);观察组治疗后血清IL-1β和TNF-α水平均低于对照组(P＜0.05)。结论 正念训练可以提高慢性失眠障碍患者治疗效果,可改善患者睡眠质量,减轻患者炎症反应。
Abstract
Objective To explore the therapeutic effect of mindfulness training on chronic insomnia patients and its impact on inflammatory factors. Methods A total of 82 patients with chronic insomnia disorder (CID) diagnosed in Jilin Provincial Corps Hospital of Chinese People’s Armed Police Force from February 2022 to May 2023 were selected and divided into observation group (41 cases) and control group (41 cases).The control group received extropiclone tablet orally, and the observation group received dextropiclone tablet combined with mindfulness training therapy. The two groups were treated for 5 weeks. The total effective rate, the changes of Pittsburgh Sleep index (PSQI) and insomnia severity index (ISI) before and after treatment, depression and anxiety status and the changes of inflammatory factors were compared between the two groups. Result The total effective rate of the observation group(90.24%) was higher than that of the control group (70.73%), and the difference was significant(χ2=4.970,P=0.026). After treatment, the scores of PSQI and ISI scales in 2 groups were lower than those before treatment (P<0.05). The scores of the two scales after treatment in the observation group were lower than those in the control group (P<0.05). After treatment, the scores of Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in 2 groups were lower than before treatment (P<0.05). The scores of the two scales after treatment in the observation group were lower than those in the control group (P<0.05).After treatment, the serum levels of interleukin-1β and tumor necrosis factor (TNF) -α in 2 groups were lower than those before treatment (P<0.05); After treatment, the levels of IL-1β and TNF-α in the observation group were lower than those in the control group (P<0.05). Conclusions Mindfulness training can improve the treatment effect of patients with chronic insomnia disorder, improve the sleep quality of patients and reduce the inflammatory response of patients.
关键词
正念训练 /
慢性失眠障碍 /
治疗效果 /
炎症因子
Key words
mindfulness training /
chronic insomnia disorder /
therapeutic effect /
inflammatory factors
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