关节腔内注射制剂增强微骨折治疗软骨缺损研究进展

陈志安, 段培押, 周田华, 王江南, 谭洪波, 施荣茂

武警医学 ›› 2024, Vol. 35 ›› Issue (1) : 84-87.

PDF(952 KB)
PDF(952 KB)
武警医学 ›› 2024, Vol. 35 ›› Issue (1) : 84-87.
综述

关节腔内注射制剂增强微骨折治疗软骨缺损研究进展

  • 陈志安1, 段培押2, 周田华1, 王江南1, 谭洪波1, 施荣茂1
作者信息 +
文章历史 +

摘要

关节软骨损伤是一种常见的临床骨科疾病,微骨折(MF)已被认为是修复软骨损伤的一线技术,辅助注射药物可以促进透明软骨再生增强临床效果。本文对常用关节腔内注射制剂进行总结,为临床提供指导。

关键词

微骨折 / 关节腔注射制剂 / 软骨缺损

引用本文

导出引用
陈志安, 段培押, 周田华, 王江南, 谭洪波, 施荣茂. 关节腔内注射制剂增强微骨折治疗软骨缺损研究进展[J]. 武警医学. 2024, 35(1): 84-87
中图分类号: R874.5   

参考文献

[1] Li M Z,Yin H,Yan Z N,et al. The immune microenvironment in cartilage injury and repair[J]. Acta Biomater, 2022, 140: 23-42.
[2] Lu Y, Zhou L,Wang L J, et al. The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress[J].Aging (Albany NY), 2020, 12: 9000-9013.
[3] Patel S, Marrone W. The Evolution of Rehabilitation and Return to Sport Following Cartilage Surgery[J]. Int J Sports Phys Ther,2023,V18:551-557.
[4] Kato Y, Nakasa T, Sumii J, et al. Changes in the subchondral bone affect pain in the natural course of traumatic articular cartilage defects[J]. Cartilage,2023,14:247-255.
[5] Jiang S P,Guo W M, Tian G Z, et al. Clinical application status of articular cartilage regeneration techniques: tissue-engineered cartilage brings new hope[J].Stem Cells Int, 2020, 2020: 5690252
[6] Cabral J, Duart J. Osteochondritis dissecans of the knee in adolescents: how to treat them[J]. J Child Orthop,2023,17:54-62.
[7] Singh D, Lindsay S, Gurbaxani S, Crawford A, et al. Elastomeric porous poly(glycerol sebacate) methacrylate (PGSm) microspheres as 3D scaffolds for chondrocyte culture and cartilage tissue engineering[J]. Int J Mol Sci,2023,24:10445.
[8] Wu Y, Lu X, Li M, et al. Renin-angiotensin system in osteoarthritis: a new potential therapy[J].Int Immunopharmacol, 2019,75:105796.
[9] Pramusita A, Kitaura H, Ohori F, et al. Salt-sensitive hypertension induces osteoclastogenesis and bone resorption via upregulation of angiotensin Ⅱ type 1 receptor expression in osteoblasts[J]. Front Cell Dev Biol, 2022,10:816764.
[10] Kobayashi T, Uehara K, Ota S, et al. The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury[J]. J Appl Physiol (1985), 2013, 114(2):262-273.
[11] Utsunomiya H, Gao X, Deng Z, et al. Biologically regulated marrow stimulation by blocking TGF-beta1 with losartan oral administration results in hyaline-like cartilage repair: a rabbit osteochondral defect model[J]. Am J Sports Med, 2020,48(4):974-984.
[12] Logan C A,Gao X,Utsunomiya H, et al. The beneficial effect of an intra-articular injection of losartan on microfracture-mediated cartilage repair is dose dependent[J].Am J Sports Med, 2021, 49: 2509-2521.
[13] Chan C K F,Gulati G S,Sinha R, et al. Identification of the human skeletal stem cell[J].Cell, 2018, 175: 43-56.e21.
[14] Chan C K F,Seo E Y,Chen J Y, et al. Identification and specification of the mouse skeletal stem cell[J].Cell, 2015, 160: 285-298.
[15] Murphy M P,Koepke L S,Lopez M T, et al. Articular cartilage regeneration by activated skeletal stem cells[J].Nat Med, 2020, 26: 1583-1592.
[16] Lu J S,Zhang H Y,Cai D Z, et al. Positive-feedback regulation of subchondral h-type vessel formation by chondrocyte promotes osteoarthritis development in mice[J].J Bone Miner Res, 2018, 33: 909-920.
[17] Zeng N, Chen Y, Wu Y, Zang M, et al. Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering[J]. Front Bioeng Biotechnol,2023,11:1196521.
[18] Juncan AM, Moisă DG, Santini A, et al. Advantages of hyaluronic acid and its combination with other bioactive ingredients in cosmeceuticals[J]. Molecules,2021,26:4429.
[19] Fallacara A,Baldini E,Manfredini S, et al. Hyaluronic acid in the third millennium[J].Polymers (Basel), 2018, 10: undefined.
[20] Everts P A, van E A, De S A, et al. Platelet rich plasma in orthopedic surgical medicine[J]. Platelets,2021,32:163-174.
[21] Riewruja K, Phakham S, Sompolpong P, et al. Cytokine profiling and intra-articular injection of autologous platelet-rich plasma in knee osteoarthritis[J]. Int J Mol Sci, 2022,23:890.
[22] Zhang Y, Wang X, Chen J, et al. Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis[J]. J Nanobiotechnology, 2022,20:56
[23] Yang Z J,Wu Y,Yin K, et al. The therapeutic value of arthroscopic microfracture technique in combination with platelet-rich plasma injection for knee cartilage injury[J].Am J Transl Res, 2021, 13: 2694-2701.
[24] Yasui Y,Dankert J F,Tonogai I, et al. The effect of single vs serial platelet-rich plasma injections in osteochondral lesions treated with microfracture: an in vivo rabbit model[J].Am J Sports Med, 2021, 49: 3876-3886.
[25] Johnson K, Zhu S, Tremblay M S, et al. A stem cell-based approach to cartilage repair[J]. Science, 2012,336(6082):717-721.
[26] Hou M, Zhang Y, Zhou X, et al. Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis[J]. Cell Death Dis,2021,12:483.
[27] Xu X, Shi D, Shen Y, et al. Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin[J]. Arthritis Res Ther,2015,17:20.
[28] Zhang M, Wang W, Wang H, et al. Downregulation of insulin-like growth factor-1 receptor mediates chondrocyte death and matrix degradation in kashin-beck disease[J]. Cartilage, 2021,13:809S-817S.
[29] Klampfleuthner FAM, Lotz B, Renkawitz T, et al. Stage-dependent activity and pro-chondrogenic function of PI3K/AKT during cartilage neogenesis from mesenchymal stromal cells[J]. Cells, 2022,11:2965.
[30] Wen C, Xu L, Xu X, et al. Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment[J]. Arthritis Res Ther, 2021,23:277.
[31] Zhang F,Liu D B,Wang G,et al. Experimental research of articular cartilage defect repair using micro-fracture and insulin-like growth factor 1 in rabbits[J].Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2014, 28: 591-596.
[32] Li F, Cai T, Yu L, et al. FGF-18 protects the injured spinal cord in mice by suppressing pyroptosis and promoting autophagy via the AKT-mTOR-TRPML1 axis[J]. Mol Neurobiol, 2023.
[33] Zhou Z, Song W, Zhang G, et al. The recombinant human fibroblast growth factor-18 (sprifermin) improves tendon-to-bone healing by promoting chondrogenesis in a rat rotator cuff repair model[J]. J Shoulder Elbow Surg, 2022,31:1617-1627.
[34] Power J, Hernandez P, Guehring H, et al. Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model[J]. J Orthop Res, 2014,32:669-676.

基金

云南省骨科与运动康复临床医学研究中心项目(ZX20191001);军事应用研究项目;军事医学专项孵化项目

PDF(952 KB)

Accesses

Citation

Detail

段落导航
相关文章

/