目的 探讨颈椎间盘突出症行前路椎间盘切除融合术(ACDF)中单间隙椎间高度(IH)与邻椎病后再手术的相关性。方法 选取2005-01至2020-11经手术治疗的颈椎间盘突出症68例,ACDF术后3 d测量IH,根据数值分为4组:术前中立位IH的130%~140%(A组),141%~150%(B组),151%~160%(C组)及161%~170%(D组),随访观察:IH与手术节段(Cn)Cobb改善角度、C2-7Cobb改善角度、胸廓入口角(TIA)及胸1倾斜角(T1S)间的关系;发生邻椎病后上、下相邻节段IH的变化;不同IH对邻椎病后再手术的影响。结果 B组发生邻椎病后再手术率最低(7%),与B组比较,A组、C组、D组邻近节段IH下降显著,差异有统计学意义(P<0.05)。相关分析显示,椎间高度的增加值(ΔIH),与手术节段Cobb角度变化呈弱相关(r=0.426, P=0.028),与C2-7Cobb的变化值、TIA及T1S无显著相关性。C、D组中邻椎病再手术数占再手术总数71.4%。结论 术后单间隙IH大于术前IH的150%是发生邻椎病再手术的高危因素,单间隙IH达术前140%~150%,发生邻椎病最少,是较理想的IH。
Abstract
Objective To investigate the correlation between intervertebral height (IH) during anterior discectomy and fusion (ACDF) for cervical disc herniation and reoperation after adjacent segment disease (ASD). Methods A total of 68 cases of cervical disc herniation treated by operation in Jiangsu Provincial Corps Hospital of Chinese People’s Armed Police Force from January 2005 to November 2020 were selected. IH was measured 3 days after ACDF operation and divided into 4 groups according to the value. Preoperative neutral IH was, 130%-140% (group A), 141%-150% (group B), 151%-160% (group C), and 161%-170% (group D). Follow-up observation was conducted to observe three aspects, the relationship between IH and Cobb improvement angle of operative segment (Cn), C2-7Cobb improvement angle, thoracic inlet angle (TIA) and T1 slope (T1S), the IH changes in the upper and lower adjacent segments after ASD, and the effect of different IH on reoperation after ASD. Results The rate of reoperation after ASD in group B was the lowest (7%). Compared with group B, IH in adjacent segments of groups A, C and D significantly decreased (P<0.05), and the difference was statistically significant (P<0.05). Correlation analysis showed that intervertebral height increment (ΔIH) was weakly correlated with the Cobb improvement angle of operative segment (Cn) (r=0.426, P=0.028), but not significantly correlated with the change of C2-7Cobb, TIA or T1S. In group C and group D, the number of reoperation for adjacent segment disease accounted for 71.4% of the total number of reoperations. Conclusions Single gap IH greater than 150% before operation is a high risk factor for the reoperation for ASD. The 140%~150% group is characterized by the least ASD, which is a relatively ideal IH.
关键词
颈椎 /
前路椎间盘切除融合术 /
单间隙 /
椎间高度 /
邻椎病
Key words
cervical vertebra /
anterior cervical discectomy and fusion /
single gap /
intervertebral height /
adjacent segment degeneration
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Burkhardt B W,Simgen A,Wagenpfeil G,et al.Adjacent segment degeneration after anterior cervical discectomy and fusion with an autologous iliac crest graft: a magnetic resonance imaging study of 59 patients with a mean follow up of 27 years[J]. Neuro Surgery,2018,82(6):799-807.
[2] Hirvonen T,Siironen J,Marjamaa J,et al.Anterior cervical discectomy and fusion in young adults leads to favorable outcome in long-term follow-up[J].Spine J, 2020, 20(7):1073-1084.
[3] Wang F,Hou H T,Wang P,et al.Symptomatic adjacent segment disease after single-lever anterior cervical discectomy and fusion: incidence and risk factors [J]. Medicine (Baltimore),2017,96(47): e8663.
[4] Deng Y,Li G,Liu H,et al.Mid to long term rates of symptomatic adjacent-level disease requiring surgery after cervical total disc replacement compared with anterior cervical discectomy and fusion: a meta-analysis of prospective randomized clinical trials[J]. J Orthop Surg Res,2020,15(1):468.
[5] Harada G K,Alter K,Nguyen A Q,et al.Cervical spine endplate abnormalities and association with pain, disability, and adjacent segment degeneration after anterior cervical discectomy and fusion[J].Spine, 2020, 45(15): E917-E926.
[6] 卢 腾,张 廷,董 军,等.颈前路融合手术对相邻节段影响的有限元分析[J].南方医科大学学报,2017,37(1): 49-55.
[7] 张玉华,蔡宗熙,熊五一,等.颈前路植骨高度对相邻节段影响的三维有限元分析[J].中华骨科杂志,2012,37(24):1540-1548.
[8] 罗春山,欧阳北平,梁栋柱,等.颈椎前路融合术中植骨块的高度对邻近节段关节突压及椎间位移的影响[J].中国临床解剖学杂志,2016,34(3):338-342.
[9] 张 波,安 岩,宋卿鹏,等.颈椎双节段人工间盘置换术与前路减压融合术远期疗效的比较[J].中华骨科杂志,2022,42(14):880-888.
[10] Skeppholm M,Henriques T,Tullberg T.Higher reoperation rate following cervical disc replacement in a retrospective, long term comparative study of 715 patients[J].Eur Spine J,2017,26(9):2434-2440 .
[11] 祁 敏,陈华江,王新伟,等.人工颈椎间盘置换术治疗颈椎病的中长期临床疗效[J].中国脊柱脊髓杂志,2020,30(12):1062-1069.
[12] 李鹏飞,危国军,石作为,等.颈前路应用Zero-P椎间融合系统与钛板联合cage融合系统治疗颈椎病的Meta分析[J].中国脊柱脊髓杂志,2019,29(3):235-246.
[13] 林宏衡,方志超,梁梓杨,等.双节段颈前路椎间盘切除融合术应用零切迹系统或钢板联合融合器固定后颈椎生物力学变化的三维有限元研究[J].中国脊柱脊髓杂志,2023,33 (2):148-162.
[14] Kinon M D,Greeley S L,Harris J A,et al.Biomechanical evaluation comparing zero-profile devices versus fixed profile systems in a cervical hybrid decompression model: a biomechanical in vitro study[J].Spine J,2020, 20(4):657-664.
[15] 海米提·阿布都艾尼,刘 浩,王贝宇,等.颈前路减压Zero-P融合固定术后椎间隙高度变化对临床疗效和影像学参数的影响[J].中国脊柱脊髓杂志,2022,32(11):980-985.
[16] 朱彦奇,王红霞,曹 锐,等.零切迹椎间融合器与钛板椎间融合器治疗多节段颈椎病的Meta分析[J].中国脊柱脊髓杂志,2019,29(9):805-814.
[17] 逄 川,海 涌,杨晋才,等.颈椎前凸角度减小对融合术后邻近节段影响的生物力学研究[J].中华骨科杂志,2016,36(6):353-360.
[18] 陆廷盛,罗春山,欧阳北平,等.椎间撑开高度对颈椎前路融合临床结果的影响[J].中国矫形外科杂志,2021,29(3):207-210.
[19] Guo H,Sheng J,Sheng W B,et al.An eight year follow up study on the treatment of single level cervical spondylosis through intervertebral disc replacement and anterior cervical decompression and fusion[J].Orthop Surg,2020,12(3):717-726.
[20] Alhashash M,Shousha M,Boehm H,et al.Adjacent segment disease after cervical spine fusion:evaluation of a 70 patient long term follow up[J].Spine,2018,43(9):605- 609.
[21] Graham S H,Ming H L,Ling Z,et al.Severity of preoperative myelopathy symptoms affects patient reported outcomes,satisfaction,and return to work after anterior cervical discectomy and fusion for degenerative cervical myelopathy[J].Spine,2020,45(10):649-656.
[22] Patwardhan A G,Havey R M.Biomechanics of cervical disc arthroplasty: a review of concepts and current technology[J]. Int J Spine Surg,2020,14(S2):S14-S28.
[23] John J D,Kumar G S,Yoganandan N,et al.Influence of cervical spine sagittal alignment on range of motion after corpectomy: a finite element study [J].Acta Neurochir,2021,163 (1):251-257.
[24] 钟远鸣,廖俊城,霍杰钊,等.颈椎前路融合后邻近节段退变与矢状位参数[J].中国矫形外科杂志,2020,28(5):390-394.
[25] Lee M J,Dettori J R,Standaert C J,et al.Indication for spinal fusion and the risk of adjacent segment pathology:does reason for fusion affect risk?A systematic review[J].Spine,2012,37: S40-S51.
[26] Rao R D,Gore D R,Tang S J,et al.Radiographic changes in the cervical spine following anterior arthrodesis:a long team analysis of 166 patients[J].J Bone Joint Surg Am,2016,98(19):1606-1613.
[27] 玉超杰,梁 斌,丘德赞,等.颈椎融合术后邻近节段退变的相关影响因素[J].中国脊柱脊髓杂志,2016,26(6):494-501.