表观遗传调控对幽门螺杆菌阳性胃癌致病作用的研究进展

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武警医学 ›› 2024, Vol. 35 ›› Issue (2) : 169-173.

综述

表观遗传调控对幽门螺杆菌阳性胃癌致病作用的研究进展

高春^1,2, 江晶晶^1,2, 陈玉春¹, 于晓辉¹, 郑晓凤³, 张久聪¹

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Research progress on epigenetic regulation in pathogenesis of Helicobacter pylori positive gastric cancer

GAO Chun, JIANG Jingjing, CHEN Yuchun, et al

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摘要

幽门螺杆菌(Hp)是一种常见的致癌因素,与胃癌的发病密切相关。幽门螺杆菌通过多种机制影响宿主基因的表达,包括表观遗传调控。随着对表观遗传学的深入研究,它与Hp阳性胃癌之间相互作用的证据也逐渐增多,靶向表观遗传学的改变有望成为Hp阳性胃癌的一种治疗策略。因此,该文对表观遗传调控在Hp阳性胃癌致病机制的影响及相互作用作一简要综述。

关键词

幽门螺杆菌 / 表观遗传学 / 胃癌 / 甲基化

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高春, 江晶晶, 陈玉春, 于晓辉, 郑晓凤, 张久聪. 表观遗传调控对幽门螺杆菌阳性胃癌致病作用的研究进展[J]. 武警医学. 2024, 35(2): 169-173

GAO Chun, JIANG Jingjing, CHEN Yuchun, et al. Research progress on epigenetic regulation in pathogenesis of Helicobacter pylori positive gastric cancer[J]. Medical Journal of the Chinese People Armed Police Forces. 2024, 35(2): 169-173

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