目的 探讨CT特征分析对不典型或早期高原肺水肿(HAPE)的诊断价值。方法 回顾性分析50例经临床诊断为早期HAPE的患者胸部CT特征,总结CT对早期高原肺水肿的诊断价值。结果 50例中,病灶发生部位累及单侧肺35例,其中右肺25例,左肺10例;累及双侧肺15例。35例病变局限于1个肺叶,10例病变发生在2个肺叶,5例病变累及3个及以上肺叶。CT表现早期HAPE胸部CT影像学特征包括双肺支气管-血管束增多、增粗,浅淡磨玻璃样改变,多角形、类圆形及小斑片状密度增高影,网格状改变,肺野外带结节影,主肺动脉内径增宽,叶间胸膜增厚,代偿性肺气肿等。结论 胸部CT检查是诊断HAPE的重要方法之一,可明显提高早期或不典型HAPE的诊断准确率。
Abstract
Objective To evaluate the diagnostic value of CT features in atypical or early high-altitude pulmonary edema (HAPE). Methods The CT features of chest of 50 patients with early HAPE were analyzed retrospectively, and the diagnostic value of CT in early HAPE was summarized. Results Among the 50 cases, 35 cases involved unilateral lung and 15 cases involve bilateral lung, including 25 cases of right lung and 10 cases of left lung. Bilateral lung was involved in 15 cases. The lesions were localized in one lobe in 35 cases, in two lobes in 10 cases, and in three or more lobes in 5 cases. Early HAPE chest CT imaging features included increased and thickened bronchial-vascular bundles in both lungs, light ground-glass like changes, polygonal, quasi circular and small patchy high-density shadows, grid-like changes, nodule shadows in the lateral field of the lung, widened inner diameter of main pulmonary artery, thickened interlobular pleural, and compensatory emphysema. Conclusions Chest CT examination is one of the most important methods in the diagnosis of HAPE, which can significantly improve the diagnostic accuracy of early or atypical HAPE.
关键词
高原地区 /
早期 /
肺水肿 /
磨玻璃密度影 /
实变影
Key words
high-altitude area /
early stage /
pulmonary edema /
grinding glass density shadow /
real variable shadow
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参考文献
[1] 胡明冬,李 琦,贺斌峰,等. 高原过度通气试验诊断早期肺水肿的临床研究[J]. 中华肺部疾病杂志, 2016,9(6): 617-620.
[2] 陆再英,钟南山.内科学[M].9版. 北京: 人民卫生出版社, 2018:967-968.
[3] 罗 帆,梁青山,张西南,等. 久居高原官兵罹患高原肺水肿1例[J]. 武警医学, 2023,36(2):173-174.
[4] 医学会第三次全国高原医学学术讨论会推荐稿. 我国高原病命名、分型及诊断标准[J].高原医学杂志, 2012,20(1):1-9.
[5] 靳永芳. 高原性肺水肿62例影像分析[J]. 影像研究与医学应用, 2018,2(20):49-50.
[6] 刘子泉,崔欢欢,刘燕青,等. 高原肺水肿的诊断、治疗与预防[J]. 中华灾害救援医学, 2021,9(8):1162-1166.
[7] 李文哲,李 凯,张 楠,等. 高原肺水肿与新型冠状病毒肺炎计算机断层扫描特征及影像鉴别[J]. 生物医学工程学杂志, 2020,37(6):1031-1036.
[8] 曹 轶,赵一蓉. 高原肺水肿的影像学特征及早期诊断价值[J]. 影像研究与医学应用, 2019,3(18):8-10.
[9] 田序伟,马爱琳,蒋刘江,等. 基于CT图像的纹理分析在鉴别高原肺水肿与急性心源性肺水肿中的价值[J]. 放射学实践, 2020,35(1):45-49.
[10] 高文祥,吴 刚,徐立聪,等. 高原肺水肿发生机制与临床转化的现状与展望[J]. 生物医学转化, 2021,2(2):1-7.
[11] Khan M, Khan M, Bordes S, et al. Physiology,pulmonary vasoconstriction[J]. Treasure Island(FL), 2020, 1:1-25.
[12] Dehnert C, Mereles D, Greiner S, et al. Exaggerated hypoxic pulmonary vasoconstriction without susceptibility to high altitude pulmonary edema[J]. High Alt MedBiol, 2015, 16(1): 11-17.
[13] Sartori C, Vollenweider L, Ffler B M, et al. Exaggerated endothelin releasein high-altitude pulmonary edema[J]. Circulation, 1999, 99(20): 2665-2668.
[14] Sharma M, Singh S B, Sarkar S. Genome wide expression analysis suggests perturbation of vascular homeostasis during high altitude pulmonary edema[J]. PLoS One, 2014, 9(1): e85902.
[15] Eichstaedt C A, Mairbäurl H,Song J,et al. Genetic Predisposition to High-Altitude Pulmonary Edema[J]. High Alt Med Biol, 2020, 21: 28-36.
[16] Mulchrone A, Moulton H, Eldridge M W, et al. Susceptibility to high-altitude pulmonary edema is associated with increased pulmonary arterial stiffness during exercise[J]. J Appl Physiol, 2020,128:514-522.
[17] Korzeniewski K,Nitsch O A,Guzek A,et al. High altitude pulmonary edema in mountain climbers[J]. Respir Physiol Neurobiol, 2015, 209(5):33-38.
[18] Macinnis M J,Koehle M S,Rupert J L.Evidence for a genetic basis for altitudeillness:2010 update[J]. Highalt Med Biol, 2010, 11(4): 349-368.
[19] Lorenzo V F, Yang Y, Simonson T S, et a1. Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation han Chinese family[J]. Blood Cells Mol Dis, 2009, 43(3): 221-225.
[20] Wilkins M R, Ghofrani H A, Weissmann N, et al. Pathophysiology and treatmeng of high altitude pulmo-Nary vascular disease[J]. Circulation, 2015, 131(6): 582-590.
[21] 张晓华. 探讨高原性肺水肿患者的临床影像学特征及影像诊断价值[J]. 影像研究与医学应用, 2018, 2(19): 43-44.