目的 了解某部新入伍人员的水痘免疫状况及抗体阳性率,为军队人员疫苗防控政策提供流行病学数据。方法 采用整群抽样法对903名新入伍人员基本信息进行收集并分析,采集静脉血进行血清分离,采用水痘-带状疱疹病毒(VZV)IgG抗体ELISA试剂盒进行检测。结果 903名入选的新入伍人员中,有198名曾经患过水痘,20名患过带状疱疹。903份血清标本中,共检出VZV IgG抗体阳性标本617份,阳性率为68.33%。结论 新入伍人员VZV IgG抗体阳性率较低,提示加强水痘疫苗接种,对军队中水痘防控具有重要意义。
Abstract
Objective To investigate the varicella zoster immunization status and antibody positive rate of new recruits in a certain unit, and to provide epidemiological data for the vaccine prevention and control policy of military personnel. Methods The basic information of 903 new recruits collected and analyzed by cluster sampling method. Venous blood was collected for serum separation and detected by varicella-herpes zoster virus (VZV) IgG antibody ELISA kit. Results Among the 903 enlisted soldiers, 198 had been contracted by chickenpox and 20 had been contracted by herpes zoster. Out of 903 serum samples, 617 VZV IgG antibody samples were detected, with a positive rate of 68.33%. Conclusions The positive rate of VZV IgG antibody in new recruits is low, suggesting that strengthening varicella-vaccination is important for the prevention and control of varicella-transmission in military units.
关键词
新入伍人员 /
水痘-带状疱疹病毒 /
IgG抗体
Key words
new recruit /
varicella-herpes zoster virus /
IgG antibody
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Gustafson T L, Lavely G B, Brawner E R Jr, et al. An outbreak of airborne nosocomial varicella[J]. Pediatrics,1982,70:550-556.
[2] Mueller N H, Gilden D H, Cohrs R J,et al.Varicella zoster virus infection:Clinical features, molecular pathogenesis of disease and latency[J].Neurol Clin, 2008, 26:675-697.
[3] 佟立波, 王 朔, 潘 辉, 等.某部2006-2015年呼吸道传染病流行病学分析[J].解放军预防医学杂志, 2017,35(4):330-333。
[4] Bonanni P,Breuer J,Gershon A,et al.Varicella vaccination in Europe-taking the practical approach[J].BMC Med, 2009, 7:26.
[5] Marin M, Guris D, Chaves S S. Prevention of varicella:Recommendations of the advisory committee on immunization practices(ACIP).Centers for disease control and prevention[J].MMWR Recomm Rep,1996,45:136.
[6] Varicella vaccines:WHO position paper[J].Wkly Epidemiol Rec,1998,73:241-248.
[7] Schmid D S.Impact of varicella vaccine on varicella-zoster virus dynamics[J].Clin Microbiol Rev, 2010,23:202-217.
[8] Meyer P A, Seward J F. Varicella mortality: trends before vaccine licensure in the United States: 1970-1994[J]. J Infect Dis, 2000,182:383-390.
[9] Marin M, Zhang J X,Seward J F.Near elimination of varicella deaths in the US after implementation of the vaccination program[J]. Pediatrics, 2011,128:214-220.
[10] 代 佩,王晓南,张 迟,等.2008-2017年湖北省水痘流行病学分析[J].现代预防医学, 2018,45(16):2885-2890.
[11] 赵红平,涂秋凤,宋丽新,等.2009-2013年江西省水痘流行病学特征分析[J].现代预防医学,2015,42(20):3649-3651.
[12] 沈金花,朱 祺,陈文花,等.2013-2014年上海市松江区水痘暴发疫情分析[J].现代预防医学,2016,43(5):919-921.
[13] Varicella Vaccination in the European Union.Available from: http://ecdc.europa.eu/en/ publications/Publications/Varicella-Guidance-2015.pdf.[Accessed on Dec 6th,2016].
[14] Bozzola E, Bozzola M. Varicella complications and universal immunization[J].J Pediatr(Rio J),2016,92:328-330.
[15] Varicella, Zoster V.WHO position paper[J].Wkly Epidemiol Rec,2014,89:265-287.
[16] Shah S S,Wood S M, Luan X, et al.Decline in varicella-related ambulatory visits and hospitalizations in the United States since routine immunization against varicella[J].Pediatr Infect Dis J,2010,29:199-204.
[17] Marin M, Zhang J X, Seward J F. Near elimination of varicella deaths in the US after implementation of the vaccination program[J]. Pediatrics, 2011,128:214-220.
[18] Nguyen H Q, Jumaan A O, Seward J F.Decline in mortality due to varicella after implemen- tation of varicella vaccination in the United States[J].N Engl J Med, 2005, 352:450-458.
[19] Boelle P Y, Hanslik T. Varicella in non-immune persons:incidence, hospitalization and mortality rates[J].Epidemiol Infect, 2002, 129:599-606.
PDF(1059 KB)
