目的 探讨富含血小板血浆(PRP)联合自体骨移植治疗骨缺损的疗效及其影响因素。方法 选择2023-01至 2023-12在火箭军特色医学中心骨科门诊及住院的骨缺损患者60例作为研究对象,依据随机数字表法分为试验组(30例)和对照组(30例)。试验组采用PRP联合自体骨移植治疗,对照组采用单纯自体骨移植治疗,比较两组患者的骨愈合时间、骨愈合率、骨密度、骨强度、骨形态评分、美国下肢功能评分(LEFS评分)和疼痛视觉模拟评分(VAS评分),采用多元线性回归和多元logistic回归分析影响骨愈合的因素。结果 试验组的骨愈合时间、骨愈合率、骨密度、骨强度和骨形态评分均明显优于对照组,差异均有统计学意义(P<0.05),且无严重的术后并发症发生。多元回归分析显示,PRP治疗是骨愈合时间和骨愈合率的独立影响因素(P<0.05)。结论 PRP联合自体骨移植是一种安全、有效、可行的治疗骨缺损的方法,能够促进骨缺损的愈合和修复,提高骨愈合质量和患者的生活质量。
Abstract
Objective To evaluate the therapeutic effect of platelet-rich plasma (PRP) combined with autologous bone grafting in the treatment of bone defect and its influence on bone repair. Methods Sixty patients with bone defect admitted to Characteristics Medical Center of PLA Rocket Army from January 2023 to December 2023 were selected as the research subjects, and were divided into two groups according to the random number table method, the experimental group (30 cases) and the control group (30 cases). The experimental group was treated with PRP combined with autologous bone grafting, while the control group was treated with simple autologous bone grafting. The two groups were compared in terms of bone healing time, bone healing rate, bone density, bone strength, bone morphology scoring, LEFS scoring, and VAS scoring. Multivariate linear regression and multivariate logistic regression analyses were used to identify factors influencing bone healing. Results The experimental group showed significantly better outcomes in terms of bone healing time, bone healing rate, bone density, bone strength, and bone morphology scoring compared with the control group, with statistically significant differences (P<0.05), and no serious postoperative complications occurred. Multivariate regression analysis indicated that PRP treatment was an independent influencing factor for bone healing time and bone healing rate (P<0.05). Conclusions PRP combined with autologous bone grafting is a safe, effective, and feasible treatment for bone defect, which can promote the healing and repair of bone defect, improve the quality of bone healing, and enhance patients' quality of life.
关键词
富含血小板的血浆 /
自体骨移植 /
骨缺损 /
骨修复
Key words
platelet-rich plasma /
autologous bone grafting /
bone defect /
bone repair
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基金
国家卫生健康委基金项目(面上项目2021KYSHX02303)
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