目的 探讨某三甲医院周边区域妇女宫颈HPV感染状况及相关风险因素。方法 选取常住在武警特色医学中心周边10 km以内,并于2020-01至2023-07在该中心妇科门诊自然就诊的妇女为研究对象,通过问卷调查、宫颈上皮脱落细胞HPV分型检测,对HPV感染状况及与感染相关因素进行统计学分析。结果 该中心周边区域自然就诊的女性共入选5967名,宫颈HPV感染1122例,感染率为18.80%,其中单一感染占78.61%(882/1122),多重感染占21.39%(240/1122)。多重感染包括2～5种HPV亚型的混合感染,其中双重感染率2.77%(165/5967),三重感染率1.06%(63/5967),四重感染率0.15%(9/5967),五重感染率0.05%(3/5967)。HPV高危型单一感染率12.42%(741/5967),HPV低危型单一感染率2.36%(141/5967)。感染率由高到低排名前5位的依次为52型(3.17%)、16型(2.92%)、53型(2.66%)、58型(1.66%)、56型(1.46%)。既往性伙伴个数(OR 1.559, 95%CI 1.409～1.724)和初次性生活年龄(OR 0.820, 95%CI 0.707～0.952)是HPV感染的相关风险因素。结论 该区域内自然就诊的妇女感染HPV亚型有自身特点,以单一感染为主,HPV型别以52型、16型、53型、58型和56型为主,既往性伙伴人数和初次性生活年龄是HPV感染的相关风险因素。
Abstract
Objective To explore the cervical HPV infection status and related risk factors among women in the vicinity of a 3A hospital. Methods The women who resided around Characteristics Medical Center of Chinese People’s Armed Police Force and naturally visited the gynecological outpatient department from January 2020 to July 2023 were selected as the study subjects. Through questionnaire survey and detection of HPV typing of cervical epithelial exfoliated cells, HPV infection status and related factors were statistically analyzed. Results A total of 5967 women were selected, and 1122 cases were infected with cervical HPV, with HPV infection rate of 18.80% (1122/5967), of which single infection accounted for 78.61% (882/1122) and multiple infections accounted for 21.39% (240/1122). Multiple infections include mixed infections of 2 to 5 HPV subtypes, with a dual infection rate of 2.77% (165/5967), triple infection rate of 1.06% (63/5967), quadruple infection rate of 0.15% (9/5967), and quintuple infection rate of 0.05% (3/5967). The single infection rate of high-risk HPV was 12.42% (741/5967), and the single infection rate of low-risk HPV was 2.36% (141/5967). The top 5 infection rate from high to low were HPV 52 (3.17%), HPV 16 (2.92%), HPV 53 (2.66%), HPV 58 (1.66%) and HPV 56 (1.46%). The number of previous sexual partners (OR 1.559, 95%CI 1.409-1.724) and age of first sexual intercourse (OR 0.820, 95%CI 0.707-0.952) were related risk factors for HPV infection. Conclusions The HPV subtypes among the women who naturally seek medical treatment in this region have their own characteristics, mainly single infection, and the HPV types were mainly 52, 16, 53, 58, and 5. The number of previous sexual partners and the age of first sexual intercourse are related risk factors for HPV infection.
关键词
人乳头瘤病毒 /
感染亚型 /
风险因素 /
宫颈癌 /
HPV疫苗
Key words
human papilloma virus /
infection subtype /
risk factor /
cervical cancer /
HPV vaccine
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