目的 探讨老年人握力减弱与静脉血栓栓塞症(VTE)发病风险的因果关系。方法 运用孟德尔随机化(MR)方法,分析握力减弱与VTE发病风险之间的因果关联,因果效应主要采用逆方差加权法(IVW)进行评估。计算F统计量检验工具变量的稳定性,运用Cochran’s Q统计法进行异质性检验,并运用加权中位数、MR-Egger回归和留一法评估敏感性和多效性。结果 老年人群握力减弱与VTE发病风险之间无因果关联(OR:1.001,95%CI:0.997~1.005,P= 0.524)。进一步分析老年人群握力减弱与深静脉血栓形成(DVT)和肺栓塞(PE)的因果关联后,老年人群握力减弱与DVT(OR:1.002,95%CI:0.999~1.006,P= 0.254)和PE发病风险之间均无因果关联(OR:0.894,95%CI:0.700~1.141,P= 0.368)。结论 老年人群的握力减弱与VTE发病风险无因果关联。
Abstract
Objective To investigate causal association between weakened grip strength and the risk of venous thromboembolism (VTE) in the elderly. Methods The association between weakened grip strength and the risk of VTE was analyzed using Mendelian randomization (MR), and the causal effect was mainly assessed with inverse variance weighting (IVW). The F-statistic was calculated to test the stability of instrumental variables, Cochran's Q-statistic was applied to test for heterogeneity, and sensitivity and pleiotropy were assessed using weighted median, MR-Egger regression and leave-one-out methods. Results There was no causal association between weakened grip strength and the risk of VTE in the elderly (OR: 1.001, 95% CI: 0.997-1.005, P=0.524). In a further analysis of deep vein thrombosis (DVT) and pulmonary embolism (PE), similarly no causal association was found between weakened grip strength and the risk of DVT (OR: 1.002, 95% CI: 0.999-1.006, P=0.254) and PE (OR: 0.894, 95% CI: 0.700-1.141, P=0.368) in the elderly. Conclusions There is no causal association between weakened grip strength and the risk of VTE in the elderly.
关键词
老年人 /
孟德尔随机化 /
握力 /
静脉血栓栓塞症
Key words
the elderly /
mendelian randomization /
grip strength /
venous thromboembolism
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基金
中国医学科学院临床与转化医学研究专项(CIFMS)(2022-I2M-C&T-B-040);中国医学科学院阜外医院深圳医院国家心血管疾病临床医学研究中心深圳自主课题(NCRCSZ-2023-015)
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