高原缺氧环境下HIF-1α和Nrf2加重炎症性肠病的机制研究进展

刘铭君, 张兴光, 刘涛涛, 李灵剑, 夏时海

武警医学 ›› 2025, Vol. 36 ›› Issue (10) : 907-911.

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武警医学 ›› 2025, Vol. 36 ›› Issue (10) : 907-911.
综述

高原缺氧环境下HIF-1α和Nrf2加重炎症性肠病的机制研究进展

  • 刘铭君1,2, 张兴光2, 刘涛涛2, 李灵剑1,2, 夏时海2
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文章历史 +

摘要

炎症性肠病(IBD)是一种复杂的慢性肠道炎症性疾病,受环境、遗传易感性及免疫失调等多种因素影响。高原缺氧环境通过加重肠黏膜屏障损伤、氧化应激及免疫紊乱等方式,加速IBD进展。HIF-1α和Nrf2是细胞应对缺氧的关键调控因子,二者通过协同与拮抗的双重作用影响肠道稳态。本文综述高原缺氧环境下,HIF-1α与Nrf2对IBD的病理生理影响的分子机制,为高原地区IBD的精准干预提供理论依据。

关键词

HIF-1α / Nrf2 / 高原缺氧环境 / 炎症性肠病

引用本文

导出引用
刘铭君, 张兴光, 刘涛涛, 李灵剑, 夏时海. 高原缺氧环境下HIF-1α和Nrf2加重炎症性肠病的机制研究进展[J]. 武警医学. 2025, 36(10): 907-911
中图分类号: R574   

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