阻塞性睡眠呼吸暂停对动脉粥样硬化影响机制的研究进展

束长城, 严鹏飞, 张敏, 马跃, 李新霞, 李金明

武警医学 ›› 2025, Vol. 36 ›› Issue (11) : 989-992.

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武警医学 ›› 2025, Vol. 36 ›› Issue (11) : 989-992.
综述

阻塞性睡眠呼吸暂停对动脉粥样硬化影响机制的研究进展

  • 束长城, 严鹏飞, 张敏, 马跃, 李新霞, 李金明
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摘要

阻塞性睡眠呼吸暂停(OSA)是一种以睡眠期间反复上气道塌陷、间歇性缺氧及睡眠结构紊乱为特征的现象。作为OSA的核心病理特征,慢性间歇性缺氧(CIH)促进动脉粥样硬化(AS)发生发展的机制研究备受关注。众多研究指出,OSA通过炎症反应、氧化应激、交感神经系统激活、血管内皮功能障碍等直接因素和血脂异常、胰岛素抵抗和血压增高等间接因素影响AS的发生发展。但具体影响机制尚未彻底揭示,仍需要进一步深入研究。本文就其可能的机制进行综述,以期为临床诊疗和预防心脑血管疾病提供参考。

关键词

阻塞性睡眠呼吸暂停 / 睡眠结构紊乱 / 动脉粥样硬化 / 慢性间歇性缺氧 / 氧化应激

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束长城, 严鹏飞, 张敏, 马跃, 李新霞, 李金明. 阻塞性睡眠呼吸暂停对动脉粥样硬化影响机制的研究进展[J]. 武警医学. 2025, 36(11): 989-992
中图分类号: R766   

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