目的 分析长期小剂量阿奇霉素治疗支气管扩张症的疗效。方法 选择2021-06至2024-03武警内蒙古总队医院收治的支气管扩张症98例,按随机数字表法分为两组,对照组49例行常规对症治疗,观察组49例在对照组基础上长期接受小剂量阿奇霉素治疗,6个月后比较两组临床疗效、呼吸困难程度、痰液性状及气道炎性程度。结果 治疗后,观察组总有效率91.84%,高于对照组的75.51%(P＜0.05);观察组圣乔治呼吸问卷(SGRQ)评分(44.33±13.69)分,低于对照组的(58.88±14.29)分,改良英国医学研究委员会呼吸困难量表(mMRC)评分(2.08±0.40)分,低于对照组的(2.71±0.46)分,差异均有统计学意义(P＜0.05);观察组24 h痰液量少于对照组,痰液密度及脓性黏液评分均低于对照组,痰液白介素-6(IL-6)、65亚基蛋白(p65)及超敏C反应蛋白(hs-CRP)表达低于对照组,差异均有统计学意义(P＜0.05)。结论 支气管扩张症患者长期接受小剂量阿奇霉素治疗的临床价值显著,有助于提升患者疗效,缓解呼吸困难程度,促进痰液性状及气道炎性程度改善。
Abstract
Objective To analyze the curative effect of long-term low-dose azithromycin in the treatment of bronchiectasis. Methods A total of 98 patients with bronchiectasis admitted to Inner Mongolian Autonomous Regional Corps Hospital of Chinese People's Armed Police Force from June 2021 to March 2024 were divided into a control group and an observation group, with 49 cases in each group according to random number table method, The control group received conventional symptomatic treatment, while the observation group received long-term low-dose azithromycin treatment on the basis of the control group. After 6 months, the clinical efficacy, dyspnea, sputum characteristics and airway inflammation were compared between the two groups. Results After treatment, the total effective rate of the observation group was 91.84%, which was higher than that of the control group (75.51%) (P<0.05). The Saint George's Respiratory Questionnaire (SGRQ) score of the observation group was (44.33±13.69), which was lower than that of the control group (58.88±14.29). The modified Medical Research Council Dyspnea Scale (mMRC) score was (2.08±0.40), which was lower than that of the control group (2.71±0.46). The differences were statistically significant (P<0.05). The 24-hour sputum volume of the observation group was lower than that of the control group, and the sputum density and purulent mucus scores were lower than those of the control group. The expressions of sputum interleukin-6 (IL-6), 65 subunit protein (p65) and high-sensitivity C-reactive protein (hs-CRP) were lower than those of the control group. The differences were statistically significant (P<0.05). Conclusions The clinical value of long-term low-dose azithromycin treatment for bronchiectasis is significant, which is helpful to improve the curative effect of patients, relieve the degree of dyspnea, and promote the improvement of sputum characteristics and airway inflammation.
关键词
支气管扩张症 /
小剂量 /
阿奇霉素 /
呼吸困难 /
痰液性状 /
气道炎性
Key words
bronchiectasis /
low dose /
azithromycin /
dyspnea /
sputum characteristics /
airway inflammation
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