控暴剂——辣椒油树脂刺激剂的损伤影响及治疗研究进展

关树梅, 石磊, 马晓蕾, 郭敬涵, 王梓琪, 苏彬

武警医学 ›› 2025, Vol. 36 ›› Issue (3) : 255-258.

PDF(927 KB)
PDF(927 KB)
武警医学 ›› 2025, Vol. 36 ›› Issue (3) : 255-258.
综述

控暴剂——辣椒油树脂刺激剂的损伤影响及治疗研究进展

  • 关树梅1, 石磊1, 马晓蕾1, 郭敬涵2, 王梓琪2, 苏彬2
作者信息 +
文章历史 +

摘要

辣椒油树脂是第三代防暴剂的主要成分,高浓度、长时间暴露可能导致严重损伤甚至死亡。辣椒油树脂损伤主要集中于眼睛、皮肤、呼吸系统,损伤程度与暴露浓度和时间有关;其致伤机制尚不完全清楚,可能与诱发神经源性炎症反应有关。干预治疗的策略主要是脱离暴露、充分清洗及对症支持治疗,严重个体需系统治疗。本文就辣椒油树脂刺激剂的发展应用、损伤效应、致伤机制及干预治疗进行综述,为临床采取综合措施,实施针对性干预治疗提供依据。

关键词

辣椒油树脂 / 防暴剂 / 病理生理 / 治疗

引用本文

导出引用
关树梅, 石磊, 马晓蕾, 郭敬涵, 王梓琪, 苏彬. 控暴剂——辣椒油树脂刺激剂的损伤影响及治疗研究进展[J]. 武警医学. 2025, 36(3): 255-258
中图分类号: E929   

参考文献

[1] Pedro A S, Salgueiro B, Ricardo J N. Statistically sound identification of compounds by low-resolution GC-MS: Identification of tear agents in tear gas sprays[J]. Talanta, 2025, 282(1): 127-136.
[2] 王红英, 牟瑛琳, 郝焕明,等. 新型控暴剂辣椒素研究进展[J]. 警察技术, 2011, 2(1): 3-6.
[3] Munteanu M, Sandu M D, Epure C,et al.Evaluation of the temperature sensitivity of the lachrymatory irritant 2-chlorobenzalmalononitrile by differential scanning calorimetry and gas chromatography-mass spectrometry[J].Int J Knowl-Based De, 2024, 30(3):1-10.
[4] 蒲利森, 于立峣, 徐 鹏,等. 某型催泪弹引信保险距离试验方法研究 [J]. 测试技术学报, 2024, 38(1):66-70.
[5] Chau H, Wan M. Pour(tear) gas on fire?[J]. Polit SCI Res Meth, 2024, 12(1): 184-194.
[6] Leung C S, Cam W, Cheng T, et al. Voices amidst the smoke—social workers against police brutality in Hong Kong[J]. Brit J Soc Work, 2022, 52(6): 35-42.
[7] Shah A, Therkorn J, Arjomandi M,et al.Laryngeal Hypersensitivity in a Veteran Cohort with Remote Exposure to Tear Gas and Pepper Spray[J].C25. Terrorism, Inhalational Disasters, and Deployment-related Lung Disease, 2022,5(2):205-211.
[8] Mihalache I. Kirsty R. Tear gas epiphanies: protests, cultures, museums[J]. UTQ, 2022, 11(1): 546-552.
[9] Niu B. Studies on the smoke dispersion when tear gas grenades exploded in different spaces[J]. HSET, 2023, 4(14): 251-259.
[10] Frey S, Maniscalco M, Holstege P. Chemical agents encountered in protests [J]. Emerg Med Clin N Am, 2022, 40(2): 365-379.
[11] Mr L, Stin A, Larsson A, et al. Rapid screening of riot control agents using dart-td-hrms[J]. Forensic Toxicol, 2024, 42(2): 152-162.
[12] Sudar S, Imbenay L, Budi I, et al. Textual analysis for public sentiment toward national police using Crisp-dm framework [J]. RIA, 2024, 38(1): 161-172.
[13] Busker W, Van M. Toxicologic evaluation of pepper spray as a possible weapon for the uutch police force: risk assessment and efficacy[J]. Am J Foren Med Path, 1998, 19(4): 309-316.
[14] Rusdiana E, Muti'ah D, Rizqianjan I. Criminal liability against police negligence for the shooting of tear gas in kanjuruhan causing victims[J]. Tech S Sci J, 2023, 50(2): 65-78.
[15] Valerie W, Jean-Paul A, Valerie L, et al. Reversible cerebral vasoconstriction syndrome following exposure to oleoresin capsicum "pepper spray"[J]. J Stroke Cerebrovasc, 2021, 30(10): 106006-106017.
[16] Zollman M, Bragg M, Harrison A. Clinical effects of oleoresin capsicum(pepper spray) on the human cornea and conjunctiva[J]. Ophthalmology, 2010, 107(12): 2186-2189.
[17] Kearney T, Hiatt P, Birdsall E, et al. Pepper spray injury severity: ten-year case experience of a poison control system[J]. Prehosp Emerg Care, 2014, 15(8): 569-572.
[18] Watson A, Stremel R, Westdorp J. Oleoresin capsicum(CAP-STUN) toxicity from aerosol exposure[J]. Ann Pharmacother, 2016, 30(7-8): 733-735.
[19] Chan C, Vilke M, Clausen J, et al. Pepper spray's effects on a suspect's ability to breathe, research in brief[J]. BJS, 2011, 1(1): 6-7.
[20] Patowary P, Pratim M, Kishor S, et al. Cardiopulmonary function and dysregulated cardiopulmonary reflexes following acute oleoresin capsicum exposure in rats[J]. TAP, 2020, 405(1): 115188-115192.
[21] Smith G, Stopford W. Health hazards of pepper spray [J]. N C Med J, 1999, 60(5): 268-274.
[22] Recer M, Johnson B, Gleason K. An evaluation of the relative potential public health concern for the self-defense spray active ingredients oleoresin capsicum, o-chlorobenzylidene malononitrile, and 2-chloroacetophenone[J]. Regul Toxicol Pharm, 2002, 36(1): 1-11.
[23] Patowary P, Pathak P, Zaman K, et al. Research progress of capsaicin responses to various pharmacological challenges[J]. Biomed Pharmacother, 2017, 96(1): 1501-1512.
[24] Hayman M, Kam A. Capsaicin: a review of its pharmacology and clinical applications[J]. Curr Opin Crit Care, 2008, 19(5-6): 338-343.
[25] Flavio P, Roger M, Bavel D, et al. Exertional rhabdomyolysis after military training paralleled by systemic microvascular dysfunction and plasma cytokine Increase: a case report[J]. Arq bras Cardiol, 2019, 113(2): 294-298.
[26] Smith J, Greaves I. The use of chemical incapacitant sprays: a review[J]. J Trauma, 2002, 52(3): 595-600.
[27] Qowim A, Degaf A. Kanjuruhan tragedy in the New York times: a critical discourse analysis[J]. IJAL, 2024, 13(3): 57-68.
[28] Carron N, Yersin B. Management of the effects of exposure to tear gas[J]. BMJ, 2019, 338(1): 19-24.
[29] Blain G. Tear gases and irritant incapacitants. 1-chloroacetophenone, 2-chlorobenzylidene malononitrile and dibenz[b,f]-1,4-oxazepine [J]. Toxicol Rev, 2003, 22(2): 103-110.
[30] Agrawal Y, Thornton D, Phipps A. CS gas--completely safe a burn case report and literature review[J]. Burns, 2019, 35(6): 895-897.
[31] Breakell A, Bodiwala G. CS gas exposure in a crowded night club: the consequences for an accident and emergency department[J]. J Accid Emerg Med, 1998, 15(1): 56-67.
[32] Lei Y, Xie J, Wang Z A, et al. Can riot-control water cannon be lethal? [J]. IJEE, 2024, 6(1):199-205.
[33] Karagama G, Newton R, Newbegin R. Short-term and long-term physical effects of exposure to CS spray[J]. J Royal Soc Medicine, 2003, 96(4): 172-184.
[34] Solomon I, Kochba I, Eizenkraft E, et al. Report of accidental CS ingestion among seven patients in central Israel and review of the current literature[J]. Arch Toxicol, 2003, 77(10): 601-604.
[35] Horton K, Burgess P, Rossiter S, et al. Secondary contamination of emergency department personnel from o-chlorobenzylidene malononitrile exposure[J]. AEM, 2005, 45(6): 655-658.
[36] Hill R, Silverberg B, Mayorga D, et al. Medical hazards of the tear gas CS. A case of persistent, multisystem, hypersensitivity reaction and review of the literature[J]. Medicine, 2020, 79(4): 234-240.
[37] Varma S, Holt P. Severe cutaneous reaction to CS gas [J]. Clin Exp Dermatol, 2001, 26(1): 248-250.
[38] Sommer S, Wilkinson M. Exposure-pattern dermatitis due to CS gas[J]. Contact ermatitis, 2019, 40(1): 46-47.
[39] Watson K, Rycroft R. Unintended cutaneous reactions to CS spray[J]. Contact ermatitis, 2010, 53(1): 9-13.
[40] Stein A, Kirwan E. Chloracetophenone(tear gas) poisoning: a clinico-pathologic report[J]. J Forensic Sci, 1964, 9(3): 374-382.
[41] Ilgaz A, Uyanusta K, Arbak P, et al. Extensive exposure to tear gases in ankara[J]. Turk Thorac J, 2018,7(4): 214-222.
[42] Davey A, Moppett K. Postoperative complications after CS spray exposure[J]. Anaesthesia, 2014, 59(1): 1219-1220.
[43] Tracy S, Michael J, Stewart S, et al. A fatal case of pepper poisoning[J]. FSI, 2011, 124(1): 43-46.

PDF(927 KB)

Accesses

Citation

Detail

段落导航
相关文章

/