目的 探究认知联合运动疗法干预轻度认知功能障碍(MCI)患者的临床疗效。方法 选取2023-01至2024-06就诊于首都医科大学附属北京友谊医院的63例MCI患者,随机分为两组,研究组31例,对照组32例。两组患者均给予一般性治疗,研究组患者接受为期12周的认知运动联合训练。在训练前后及训练停止12周后分别对两组患者进行蒙特利尔认知评估量表(MoCA)评定。结果 两组患者治疗前MoCA评分无统计学差异,在认知运动联合训练结束及停止训练12周后,研究组患者MoCA量表评分较对照组均升高,差异具有统计学意义(P<0.05);研究组患者认知功能的改善主要表现在视空间/执行功能、注意、语言及记忆方面。结论 认知运动联合干预可以改善MCI患者的认知功能水平,并具有一定的持续效应。
Abstract
Objective To explore the clinical efficacy of combined intervention of exercise and cognition in patients with mild cognitive impairment (MCI). Methods A total of 63 patients with MCI were randomly divided into a study group (n=31) and a control group (n=32). Both groups received general treatment, and the study group received combined training of exercise and cognition for 12 weeks. The Montreal Cognitive Assessment Scale (MoCA) was assessed before and after the training and 12 weeks after the training was stopped. Results There was no statistical difference in MoCA scores between the two groups before treatment. After the end of combined cognitive motor training and 12 weeks after stopping training, the MoCA scores of the study group were higher than those of the control group, with statistical significance (P<0.05). The improvement of cognitive function in the study group was mainly manifested in visuospatial/executive function, attention, language and memory. Conclusions Combined intervention of exercise and cognition can improve the cognitive function of patients with MCI, and has a certain lasting effect.
关键词
认知疗法 /
运动疗法 /
轻度认知功能障碍
Key words
cognitive therapy /
exercise therapy /
mild cognitive impairment
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参考文献
[1] Lindbergh C A, Dishman R K, Miller L S. Functional disability in mild cognitive impairment: a systematic review andmeta-analysis[J]. Neuropsychology Review, 2016, 26(2):129-159.
[2] Mariani E, Monastero R, Mecocci P. Mild cognitive impairment: a systematic review [J]. J Alzheimers Dis, 2007,12: 23-35.
[3] Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study[J]. Lancet Public Health, 2020,5(12): e661-e671.
[4] Salzman T, Sarquis-adamson Y, Son S, et al. Associations of multidomain interventions with improvements in cognition in mildcognitive impairment: a systematic review and meta-analysis[J].JAMA Netw Open, 2022, 5(5): e226744.
[5] Albert M S, DeKosky S T, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J]. Alzheimers Dement, 2011, 7(3):270-279.
[6] Bai W, Chen P, Cai H, et al. Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies[J]. Age Ageing, 2022, 51(8):1-14.
[7] David A R, Pradyumna K B, Lauren A N, et al. Effects of simultaneous cognitive and aerobic exercise training on dual-task walking performance in healthy older adults: results from a pilot randomized controlled trial[J]. BMC Geriatr, 2020,20(1):83-93.
[8] You J H, Shetty A, Jones T, et al. Effects of dual-task cognitive-gait intervention on memory and gait dynamics in older adults with a history of falls: a preliminary investigation[J]. Neurorehabilitation, 2009, 24(2):193-8.
[9] Train the Brain Consortium. Randomized trial on the effects of acombined physical/cognitive training in aged MCI subjects:the train the Brain study[J]. Sci Rep,2017,7:39471.
[10] Karssemeijer E G A,Aaronson J A,Bossers W J,et al. Positive effects of combined cognitive and physical exercisetraining on cognitive function in older adults with mild cogni-tive impairment or dementia:a meta-analysis[J]. Ageing ResRev,2017,40(1):75-83.
[11] Migueles J H, Cadenas S C, Esteban C I, et al. Associations of objectively-assessed physical activity and sedentary time with hippocampal gray matter volume inchildren with overweight/obesity[J]. J Clin Med, 2020,9(4):1080.
[12] Leavitt V M, Cirnigliaro C, Cohen A, et al. Aerobic exercise increases hippocampal volumeand improves memory in multiple sclerosis: preliminary findings[J]. Neurocase,2014,20(6):695-697.
[13] Song D, Yu D S F, Li P W C, et al. The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and meta-analysis[J]. Int J Nurs Stud, 2018, 79:155-164.
[14] Zotcheva E, Bergh S, Selbæk G, et al. Midlife physical activity, psychological distress, and dementia risk: the HUNT Study[J]. J Alzheimer Dis, 2018, 66(2): 825-833.
[15] Siu M Y, Lee D T F. Effects of Tai Chi on cognition and instrumental activities of daily living in community dwelling older people with mild cognitive impairment[J]. BMC Geriatrics, 2018,18(1):37.
[16] Miller S M, Taylor P R E. Effects of Tai Chi on cognitive function in communitydwelling older adults:a review[J]. Geriatric Nursing, 2014,35(1):9-19.
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