目的 分析慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺癌的危险因素,提出相应防范策略。方法 回顾性选取2022-03至2024-03南部战区总医院收治的COPD合并肺癌患者55例作为COPD合并肺癌组,另选取同期单纯COPD患者110例作为单纯COPD组。收集两组临床资料及实验室指标等,行单因素及多因素Logistic回归分析筛选其危险因素,并绘制受试者工作特征(ROC)曲线观察其预测效能。结果 单因素Logistic回归分析显示,COPD合并肺癌组年龄≥65岁占比、男性占比、农民占比、COPD病程、吸烟指数、白细胞介素-17(IL-17)及血小板计数均高于单纯COPD组(P＜0.05);多因素Logistic回归分析显示,职业(OR＝2.231,95%CI:1.074～4.636)、吸烟指数(OR＝2.381,95%CI:1.125～5.039)、COPD病程(OR＝1.209,95%CI:1.092～1.338)、IL-17(OR＝1.374,95%CI:1.008～1.873)、血小板计数(OR＝1.072,95%CI:1.043～1.101)均为COPD合并肺癌的独立危险因素。ROC分析显示,职业、吸烟指数、COPD病程、IL-17、血小板计数对COPD合并肺癌均具有一定预测效能。结论 职业为农民、吸烟指数≥800、COPD病程长、IL-17、血小板计数高为COPD合并肺癌的独立危险因素,且具有良好的预测效能。
Abstract
Objective To analyze risk factors for chronic obstructive pulmonary disease (COPD) complicated with lung cancer and propose corresponding preventive strategies. Methods A retrospective study was conducted on 55 COPD patients complicated with lung cancer (COPD with lung cancer group) and 110 patients with COPD alone ( COPD alone group) admitted to the General Hospital of PLA Southern Theater Command from March 2022 to March 2024. Clinical data and laboratory indicators were collected. Univariate and multivariate logistic regression analyses were performed to identify risk factors, and Receiver Operating Characteristic (ROC) curves were constructed to evaluate predictive performance. Results Univariate logistic regression analysis showed that the COPD with lung cancer group had higher proportions of age ≥65 years, male patients and farmers, longer COPD duration, higher smoking index, elevated Interleukin-17 (IL-17) levels, and increased platelet count than the COPD al one group (P＜0.05) . Multivariate logistic regression analysis identified occupation ( OR=2.23 1,9 5%CI=1. 074~4. 636 ), smoking index ( OR=2. 381 ,95 % CI=1.125~5. 039 ) , COPD duration ( OR=1.209, 95% CI=1. 092~1.338 ), IL-17 ( OR=1.374 ,95%CI=1. 008~1. 873 ) , and platelet count ( OR = 1. 072,9 5 % CI = 1. 043 ~ 1. 101 ) as independent risk factors for COPD patients complicated with lung cancer. ROC analysis demonstrated that occupation, smoking index, COPD duration, IL-17 and platelet count all showed certain predictive efficacy for lung cancer in COPD patients. Conclusions Occupation as a farmer, smoking index=800, longer COPD duration, IL-17 levels, and increased platelet count are independent risk factors for COPD patients complicated with lung cancer, demonstrating good predictive efficacy.
关键词
慢性阻塞性肺疾病 /
肺癌 /
危险因素 /
防范策略
Key words
chronic obstructive pulmonary disease /
lung cancer /
risk factors /
preventive strategies
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