目的 探讨青年单纯舒张期高血压（IDH）对颈动脉结构及内皮功能的影响。方法 收集2021年度武警北京总队医院体检数据,对比IDH患者与健康对照者的颈动脉内中膜厚度（CIMT）及内皮素-1（ET-1）,并探讨二者之间与舒张压变化的关联。结果 IDH患者的CIMT高于健康对照者[（0.84±0.11）vs.（0.75±0.10）, P=0.030）],且ET-1水平也存在升高的现象[（116.63.15±20.84）vs.（103.21±23.88）, P=0.042）]。同时,CIMT与ET-1存在正相关的关系（R2=0.61, P<0.001）。结论 舒张压升高在一定程度上对颈动脉的结构和功能都有负面影响,应加强IDH的健康知识普及与早期干预。
Abstract
Objective To investigate the effects of isolated diastolic hypertension （IDH） on the structure of the carotid artery and endothelial function in young patients. Methods Physical examination data in 2021 were collected from Beijing Municipal Corps Hospital of Chinese People’s Armed Police Force. The carotid intima-media thickness （CIMT） and endothelin-1 （ET-1） of IDH patients and healthy controls were compared,and the association between the them and the changes in diastolic blood pressure was explored. Results The CIMT of IDH patients was higher than that of healthy controls [（0.84±0.11）vs.（0.75±0.10）,P=0.030], and the ET-1 level also showed an increase[（116.63.15±20.84）vs.（103.21±23.88）, P=0.042]. At the same time, there was a positive correlation between CIMT and ET-1 （R2=0.61, P < 0.001）. Conclusions The increase in diastolic blood pressure has a negative impact on the structure and function of carotid artery to a certain extent. It is necessary to strengthen the popularization of health knowledge about IDH and early intervention.
关键词
单纯舒张期高血压 /
颈动脉内中膜厚度 /
血管内皮功能 /
青年
Key words
isolated diastolic hypertension /
carotid intima-media thickness /
vascular endothelial function /
young men
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