目的 探讨两种方式注射A型肉毒毒素对治疗雄激素性脱发的疗效。方法 对2023-04至2024-04在解放军总医院海南医院皮肤科就诊,选择A型肉毒毒素治疗的男性雄激素性脱发患者进行回顾性分析。共28例患者入选本研究,根据治疗方法不同进行分组,其中15例采用肌内注射（肌内注射组）,13例采用肌内联合皮内注射（联合注射组）。采用自我评价、外观评估、毛发数评估方法,比较两组患者治疗24周后的临床疗效。结果 两组患者自我评价、头皮油腻改善、头发生长方面比较,差异无统计学意义。外观评估肌内注射组有效率为60%,肌内联合皮内注射组有效率为69.2%,差异无统计学意义（P>0.05）。两组治疗后毛发数量均较治疗前有明显增加,差异有统计学意义（P<0.05）。治疗第24周时两组毛发数比较,肌内联合皮内注射组优于肌内注射组[（176.2±44.9）vs.（160.5±31.3）],差异有统计学意义（P<0.05）。结论 肌内注射、肌内联合皮内注射A型肉毒毒素治疗雄激素性脱发均有效,且肌内联合皮内注射效果更佳。
Abstract
Objective To explore the clinical efficacy of two different injection methods of botulinum toxin A in the treatment of androgenetic alopecia. Methods A retrospective analysis was conducted on 28 male patients with androgenetic alopecia who received botulinum toxin A treatment at the department of dermatology of Hainan Hospital of PLA General Hospital from April 2023 to April 2024. A total of 28 patients were included in this study, and they were divided into groups based on different treatment methods, with 15 patients receiving intramuscular injection (intramuscular injection group), and 13 patients receiving intramuscular injection combined with intradermal injection (combined injection group). Clinical efficacy was assessed after 24 weeks of treatment using three evaluation methods： self-assessment, appearance evaluation, and hair count assessment. Results There was no statistically significant difference in self-assessment, the improvement of scalp oiliness and hair growth between the two groups（P > 0.05）. The effective rate of intramuscular injection group was 60%, and that of the combined group was 69.2%,with no statistically significant difference (P > 0.05) . In hair count assessment, both groups showed a significant increase in hair count after treatment compared to before treatment （P < 0.05）. At week 24 of treatment, the combined injection group showed superior results compared to the intramuscular injection group[（176.2±44.9）vs.（160.5±31.3）], with statistically significant difference （P < 0.05）. Conclusions Both intramuscular injection and combined intramuscular and intradermal injection of botulinum toxin A are effective in the treatment of androgenetic alopecia, and the combined injection method is more effective.
关键词
A型肉毒毒素 /
雄激素性脱发 /
治疗应用 /
肌内注射 /
皮内注射
Key words
botulinum toxin A /
androgenetic alopecia /
therapeutic use /
intramuscular injection /
intradermal injection
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