龈沟液Gal-3、asprosin与种植体周围炎患者预后的关系

冯立娜; 范卓杰

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武警医学 ›› 2025, Vol. 36 ›› Issue (6) : 505-510.

论著

龈沟液Gal-3、asprosin与种植体周围炎患者预后的关系

冯立娜, 范卓杰

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Relationship between gingival crevicular fluid Gal-3, asprosin and prognosis of patients with periimplantitis

FENG Lina, FAN Zhuojie

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摘要

目的探讨龈沟液半乳糖凝集素-3(Gal-3)、白脂素(asprosin)与种植体周围炎(PI)患者预后的关系。方法选取2021-01至2023-12解放军总医院第三医学中心收治的138例PI患者为患病组,根据预后情况分为不良组(44例)和良好组(94例);另选同期138例种植体健康者为对照组。比较龈沟液中Gal-3、asprosin的水平;龈沟液Gal-3、asprosin水平与牙周临床指标相关性采用pearson法;多因素Logistic回归分析PI患者发生预后不良的影响因素;ROC曲线分析龈沟液Gal-3、asprosin水平联合牙周临床指标对PI患者发生预后不良的预测价值。结果与对照组相比,患病组龈沟液Gal-3、asprosin水平及牙周临床指标水平均明显升高(P<0.05);龈沟液Gal-3、asprosin水平与牙周临床指标均呈正相关(r＞0.05);与良好组相比,不良组龈沟液Gal-3、asprosin水平及牙周临床指标均明显升高(P<0.05);龈沟液Gal-3、asprosin水平、PD、mGI、mSBI联合预测PI患者发生预后不良的曲线下面积(AUC)明显高于单一指标预测(Z_{五者联合-Gal-3}=2.892、Z_{五者联合-asprosin}=2.062、Z_{五者联合-PD}=2.710、Z_{五者联合-mGI}=2.929、Z_{五者联合-mSBI}=3.017,P=0.004、0.039、0.007、0.003、0.003)。结论龈沟液Gal-3、asprosin水平联合牙周临床指标对PI患者发生预后不良具有较高的预测价值。

Abstract

Objective To investigate the relationship between gingival crevicular fluid galectin-3 (Gal-3), asprosin and prognosis of patients with periimplantitis (PI). Methods A total of 138 patients with PI admitted to the Third Medical Center of PLA General Hospital from January 2021 to December 2023 were selected as the disease group, and were divided into a poor group (44 cases) and a good group (94 cases) according to their prognosis. Another 138 healthy implant patients were selected as a control group. The levels of Gal-3 and asprosin in gingival crevicular fluid were compared. The correlation between the levels of Gal-3 and asprosin in gingival crevicular fluid and periodontal clinical indicators was analyzed using Pearson’s method. Multivariate logistic regression was applied to analyze the influencing factors of poor prognosis in PI patients. ROC curve was used to analyze the predictive value of gingival crevicular fluid Gal-3 and asprosin levels combined with periodontal clinical indicators for poor prognosis in PI patients. Results Compared with control group, the levels of Gal-3 and asprosin in gingival crevicular fluid and periodontal clinical indicators in the disease group were significantly increased (P<0.05).The levels of Gal-3 and asprosin in gingival crevicular fluid were positively correlated with periodontal clinical indicators (P<0.05). Compared with the good group, the levels of Gal-3 and asprosin and periodontal clinical indicators were greatly higher in the poor group (P<0.05). The area under the curve (AUC) of Gal-3, asprosin levels, PD, mGI, and mSBI combined in predicting poor prognosis in PI patients was significantly higher than that predicted by a single indicator (Z combined prediction-Gal-3=2.892, Z combined prediction- sprosin=2.062, Z combined prediction- PD=2.710, Z combined prediction- mGI=2.929, Z combined prediction- mSBI=3.017, P=0.004, 0.039, 0.007, 0.003, 0.003). Conclusions Gingival crevicular fluid Gal-3 and asprosin levels combined with periodontal clinical indicators have high predictive value for poor prognosis in PI patients.

导出引用

冯立娜, 范卓杰. 龈沟液Gal-3、asprosin与种植体周围炎患者预后的关系[J]. 武警医学. 2025, 36(6): 505-510

FENG Lina, FAN Zhuojie. Relationship between gingival crevicular fluid Gal-3, asprosin and prognosis of patients with periimplantitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(6): 505-510

中图分类号： R781.4

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