氧化应激和自噬与牙周炎的关系研究进展

项于蓝, 栾樱译, 张栋梁

武警医学 ›› 2025, Vol. 36 ›› Issue (6) : 535-538.

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武警医学 ›› 2025, Vol. 36 ›› Issue (6) : 535-538.
综述

氧化应激和自噬与牙周炎的关系研究进展

  • 项于蓝1, 栾樱译2, 张栋梁1
作者信息 +

Research progress on the relationship between oxidative stress, autophagy and periodontitis

  • XIANG Yulan, LUAN Yingyi, ZHANG Dongliang
Author information +
文章历史 +

摘要

牙周炎(PD)是由菌斑微生物引起的牙周支持组织的慢性炎症性疾病。氧化应激是一种氧化剂的破坏作用大于抗氧化剂的有益作用的细胞状态,自噬是一类细胞内降解自身受损的细胞器和大分子物质的代谢过程,是真核生物细胞适应环境刺激的固有机制。PD可引起氧化应激,但过量的氧化应激可加重局部及全身的炎症风险,直接或间接破坏牙周组织,加重PD。此外,炎症引起的氧化应激能启动自噬,自噬可通过负向调控受体信号影响炎症反应。本文对氧化应激、自噬与PD的关系进行综述,旨在进一步探索氧化应激、自噬对PD发生发展的影响,为PD的治疗探索新途径。

关键词

氧化应激 / 自噬 / 牙周炎

引用本文

导出引用
项于蓝, 栾樱译, 张栋梁. 氧化应激和自噬与牙周炎的关系研究进展[J]. 武警医学. 2025, 36(6): 535-538
XIANG Yulan, LUAN Yingyi, ZHANG Dongliang. Research progress on the relationship between oxidative stress, autophagy and periodontitis[J]. Medical Journal of the Chinese People Armed Police Forces. 2025, 36(6): 535-538
中图分类号: R781.4+2   

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基金

中国高校产学研创新基金(2021JH039,2022BC079); 北京市科技新星计划交叉合作课题(20220484231)

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