目的 探讨载药微球栓塞与传统术式对原发性肝癌（PHC）的疗效及不良反应的差异。方法 选择2020-01至2022-12,本院收治的122例PHC患者作为研究对象,随机数字表法分为栓塞组（n=61,采取载药微球栓塞治疗）和对照组（n=61,采取传统术式）。比较两组的一般资料、治疗情况、血清指标、中性粒细胞与淋巴细胞比值、不良反应发生情况及近期疗效。结果 治疗后1、2、3个月栓塞组和对照组肿瘤数目（单个）、大小,血清γ-谷氨酰转肽酶,甲胎蛋白（AFP）比较,差异无统计学意义（P>0.05）。治疗后1、2、3个月栓塞组比对照组的碱性磷酸酶（ALP）略低（P<0.05）。治疗后3个月栓塞组中性粒细胞与淋巴细胞比值高于治疗后1个月（P<0.05）;治疗后2、3个月对照组中性粒细胞与淋巴细胞比值高于治疗后1个月（P<0.05）;治疗后1、2、3个月栓塞组比对照组的中性粒细胞与淋巴细胞比值高（P<0.05）。治疗后3个月内栓塞组不良反应总发生率低于对照组（P<0.05）。栓塞组RR、DCR人数比值高于对照组（P<0.05）。结论 载药微球栓塞和传统术式在PHC中均能达到显著疗效,但前者免疫功能改善显著,且不良反应发生率低,近期疗效优。

Objective To investigate the differences of efficacy and adverse reactions between drug-loaded microsphere embolization and traditional surgical methods for primary hepatic carcinoma （PHC）. Methods A total of 122 PHC patients admitted to Fenyang Hospital of Shanxi Province from January 2020 to December 2022 were selected as the study subjects,and were randomly divided into an embolization group （n=61, embolization with drug-loaded microsphere） and a control group （n=61, with traditional surgery） according to random number table. General data,treatment conditions,serum indexes, neutrophil-lymphocyte ratio, adverse reactions and short-term efficacy were compared between the two groups. Results There were no significant differences in the number of tumors （single）, size, serum γ-glutamyl transpeptidase or α-fetoprotein （AFP） between the two groups at 1,2 and 3 months after treatment （P>0.05）. The alkaline phosphatase （ALP） of the embolization group was slightly lower than that of the control group at 1,2 and 3 months after treatment （P<0.05）. The ratio of neutrophils to lymphocytes of the embolization group 3 months after treatment was higher than that of 1 month after treatment （P<0.05）. The ratio of neutrophils to lymphocytes of the control group was higher than that in the control group at 2 and 3 months after treatment （P<0.05）. The ratio of neutrophils to lymphocytes of the embolization group was higher than that of the control group at 1,2 and 3 months after treatment （P<0.05）. The total incidence of adverse reactions in the embolization group within 3 months after treatment was lower than that in the control group （P<0.05）. The ratio of RR and DCR in the embolization group was higher than that in the control group （P<0.05）. Conclusions Drug-loaded microsphere embolization and traditional surgical methods can both achieve significant therapeutic effects in PHC, but the former significantly improves immune function and has a lower incidence of adverse reactions and better short-term efficacy.