目的 分析2020-2022年天津地区健康查体人群中梅毒螺旋抗体筛查情况及其影响因素。方法 收集2020-01至2022-12天津地区健康查体人群血液标本159 625份,使用两种不同的酶联免疫吸附试验（ELISA）试剂检测健康查体人群血液标本中的梅毒螺旋抗体,其中男性血液标本101 127份,女性血液标本58 498份,采用统计学分析筛查情况,通过单因素和多因素Logistic回归分析影响因素。结果 2022年天津地区健康查体人群梅毒螺旋抗体检测复检符合率高于2020年和2021年,差异有统计学意义（P<0.05）;其中30~39岁、男性、单身/离异/丧偶、初中及以下、非本省籍贯、服务人员梅毒螺旋体ELISA双试剂阳性率占比较高;阳性组与阴性组年龄、性别、婚姻状况、文化程度、职业比较差异有统计学意义（P<0.05）;经多因素Logistic回归模型分析显示,年龄<50岁、男性、婚姻状况为单身/离异/丧偶、文化程度为初中及以下、职业为服务人员均为健康查体人群梅毒螺旋抗体筛查阳性的独立危险因素（P<0.05）。结论 2020-2022年天津地区健康查体人群中梅毒螺旋抗体筛查阳性率较高,年龄、性别、婚姻状况、文化程度、职业等因素对筛查阳性率有显著影响。
Abstract
Objective To analyze the screening situation and influencing factors of treponema pallidum antibodies among health examination population in Tianjin from 2020 to 2022. Methods A total of 159625 blood samples from the health examination population in Tianjin from January 2020 to December 2022 were collected. Two different enzyme-linked immunosorbent assay （ELISA） reagents were used to detect treponema pallidum antibodies in the blood samples. Among them,101127 male blood samples and 58498 female blood samples were collected. Statistical analysis was used to analyze the screening situation,and the influencing factors were analyzed through univariate and multivariate logistic regression. Results The compliance rate of syphilis spiral antibody retesting in the health examination population in 2022 was higher than that in 2020 and 2021,and the difference was statistically significant （P<0.05）. Among them, the positive rates of treponema pallidum ELISA double reagent in the 30-39 age group, men, single/divorced/widowed, those with junior high school education or below, and those with non-local place of origin were relatively high. There were statistically significant differences in age, gender, marital status, education level and occupation between the positive group and the negative group （P<0.05）. Multivariate Logistic regression model analysis showed that age < 50 years old, male, marital status of single/divorced/widowed, junior high school education level or below, and occupation as service personnel were all independent risk factors for positive screening of treponema pallidum antibody in the health examination population （P<0.05）. Conclusions The positive rate of treponema pallidum antibody screening is relatively high among the health examination population in Tianjin from 2020 to 2022. Factors such as age, gender, marital status, education level,and occupation have significant impact on the screening positive rate.
关键词
梅毒螺旋抗体 /
健康查体人群 /
筛查情况
Key words
treponema pallidum antibody /
health examination population /
screening situation
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