目的 探讨体能锻炼对高尿酸血症(HUA)青年男性血尿酸代谢及身体成分影响。方法 回顾性分析2024年春季集中生活、统一锻炼的1 069名青年男性体检资料,共48名HUA入选本研究。回顾分析每月体检复查的血尿酸及身高、体重、腰围、臀围数据,比较体能锻炼4个月期间血尿酸、体重指数(BMI)、腰臀比(WHR)变化,对尿酸水平与BMI、WHR变化进行相关性分析。结果 体能锻炼期间,第1个月起即发现血尿酸水平较基线显著下降(P<0.05),4个月时下降最为明显。4个月血尿酸降至420 μmol/L以下占比29.17%,降至540 μmol/L以下占比93.75%。锻炼期间BMI和WHR均显著下降(P<0.05),尿酸下降幅度在锻炼2个月开始与WHR下降幅度正相关(P<0.05),锻炼3个月开始与BMI下降幅度正相关(P<0.05)。结论 体能锻炼对HUA青年男性的血尿酸、BMI和WHR均有显著改善,且尿酸下降水平与二者下降存在正相关。体能锻炼结合体脂、体重管理可为HUA青年男性降低尿酸水平提供有效健康管理策略。
Abstract
Objective To explore the effects of physical exercise on serum uric acid metabolism and body composition of young adult males with hyperuricemia (HUA). Methods The physical examination data of 48 young adult males with HUA who underwent unified exercise in the spring of 2024 were sorted and analyzed. A retrospective analysis was conducted on monthly follow-up data, including serum uric acid levels, height, weight, waist circumference and hip circumference. Changes in uric acid, body mass index (BMI), and waist-to-hip ratio (WHR) during the 4-month period of physical exercise were compared, and the correlation analysis was performed between uric acid changes and changes in BMI and WHR. Results During the physical exercise period, serum uric acid levels significantly decreased compared to the baseline from the first month. (P＜0.05), with the most pronounced reduction at the 4-month mark. After 4 months, 29.17% of recruits achieved serum uric acid levels below 420 μmol/L, and 93.75% fell below 540 μmol/L. Both BMI and WHR showed significant reductions (P＜0.05). The reduction in uric acid levels was positively correlated with the decrease in WHR beginning at 2 months of exercise (P＜0.05), and began to be positively correlated with the decrease in BMI at 3 months of exercise (P＜0.05). Conclusions Physical exercise significantly improves serum uric acid levels, BMI, and WHR in young adult males with HUA, with a positive correlation observed between uric acid reduction and decreases in both BMI and WHR. Combining physical exercise with body fat and weight management can provide an effective health management strategy for the reduction of uric acid levels in young adult males with HUA.
关键词
高尿酸血症 /
体能锻炼 /
体重指数 /
腰臀比 /
青年男性
Key words
hyperuricemia /
physical exercise /
body mass index /
waist-to-hip ratio;young adult males
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参考文献
[1] Borghi C, Agabiti R E, Johnson R J, et al. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease[J]. Eur J Intern Med, 2020, 80(10): 1-11.
[2] Liu P, Kadier K, Cui C, et al. Lowering the risk of hyperuricemia and gout is associated with ideal cardiovascular health[J]. J Health Popul Nutr, 2024, 43(1): 167.
[3] 方宁远, 吕力为, 吕晓希, 等. 中国高尿酸血症相关疾病诊疗多学科专家共识(2023年版)[J]. 中国实用内科杂志, 2023, 43(6): 461-480.
[4] 高海峰, 阳吾君, 严 安, 等. 高原官兵高尿酸血症的预防及诊疗进展[J]. 武警医学, 2023, 34(5):435-437.
[5] 中国医师协会肾脏内科医师分会, 中国肾脏疾病高尿酸血症诊治的实践指南(2017版)[J]. 中华医学杂志, 2017, 97(25): 1927-1936.
[6] Zhang M, Zhu X, Wu J, et al. Prevalence of hyperuricemia among Chinese adults: findings from two nationally representative cross sectional surveys in 2015-16 and 2018-19[J]. Front Immunol, 2021, 12:791983.
[7] Niu Y, Zhang Y, Sun Y, et al. A combined association of obesity, alanine aminotransferase and creatinine with hyperuricemia in youth aged 13-20 years[J]. Front Nutr, 2024, 11:1326039.
[8] 冯颖倩, 王梦君, 张海雄, 等. 不同年龄高尿酸血症患者临床特征及其发病影响因素分析[J]. 临床和实验医学杂志, 2024, 23(2):149-153.
[9] Faienza M F, Cognetti E, Farella I, et al. Dietary fructose: from uric acid to a metabolic switch in pediatric metabolic dysfunction-associated steatotic liver disease[J]. Crit Rev Food Sci Nutr, 2024, 19:1-16.
[10] Hou Y, Ma R, Gao S, et al. The effect of low and moderate exercise on hyperuricemia: protocol for a randomized controlled study[J]. Front Endocrinol(Lausanne), 2021, 12: 716802.
[11] 蒋中业, 曹建民, 曹 卉, 等. 运动防治高尿酸血症的研究现状与展望[J]. 中国预防医学杂志, 2021, 22(5): 390-396.
[12] Biswas A, Oh PI, Faulkner G E, et al. Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis[J]. Ann Intern Med, 2015, 162(2): 123-32.
[13] Yuan S, Zhang ZW, Li Z L. Antacids’ side effect hyperuricaemia could be alleviated by long-term aerobic exercise via accelerating ATP turnover rate[J]. Biomed Pharmacother, 2018, 99: 18-24.
[14] Jiang Z, Cao J, Su H, et al. Exercise serum regulates uric acid transporters in normal rat kidney cells[J]. Sci Rep, 2022, 12(1): 18086.
[15] Zhang T, Liu W, Gao S. Exercise and hyperuricemia: an opinion article[J]. Ann Med, 2024, 56(1):2396075.
[16] 冯泽龙, 薛政昊, 陈德明. 不同运动干预方式下运动强度对高尿酸血症的治疗相关研究进展[J]. 哈尔滨体育学院学报, 2023, 41(2): 88-96.
[17] Zhou Z, Li K, Li X, et al. Independent and joint associations of body mass index, waist circumference, waist-height ratio and their changes with risks of hyperuricemia in middle-aged and older Chinese individuals: a population-based nationwide cohort study[J]. Nutr Metab(Lond), 2021, 18(1): 62.
[18] Yamada A, Sato K K, Kinuhata S, et al. Association of visceral fat and liver fat with hyperuricemia[J]. Arthritis Care Res(Hoboken), 2016, 68(4):553-61.
[19] Liang J, Jiang Y, Huang Y, et al. Comorbidities and factors influencing frequent gout attacks in patients with gout: a cross-sectional study[J]. Clin Rheumatol, 2021, 40(7): 2873-2880.
[20] Wang H P, Xu YY, Xu B L, et al. Correlation between abdominal fat distribution and serum uric acid in patients recently diagnosed with type 2 diabetes[J]. Diabetes Metab Syndr Obes, 2023, 16:3751-3762.
[21] Tao M, Liu J, Chen X, et al. Correlation between serum uric acid and body fat distribution in patients with MAFLD[J]. BMC Endocr Disord, 2023, 23(1):204.
[22] Chen D, Lu C, Chen K, et al. Association between anthropometric indices and hyperuricemia: a nationwide study in China[J]. Clin Rheumatol, 2024, 43(3):907-920.
[23] McCormick N, Rai S K, Lu N, et al. Estimation of primary prevention of gout in men through modification of obesity and other key lifestyle factors[J]. JAMA Netw Open, 2020, 3(11): e2027421.
[24] McCormick N, O’Connor M J, Yokose C, et al. Assessing the causal relationships between insulin resistance and hyperuricemia and gout using bidirectional mendelian randomization[J]. Arthritis Rheumatol, 2021, 73(11): 2096-2104.
[25] Sautner J, Eichbauer-Sturm G, Gruber J, et al. 2022 update of the austrian society of rheumatology and rehabilitation nutrition and lifestyle recommendations for patients with gout and hyperuricemia[J]. Wien Klin Wochenschr, 2022, 134(13-14): 546-554.
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