铁死亡参与急性胰腺炎发病机制的研究进展

高庆红, 许威, 夏时海

武警医学 ›› 2025, Vol. 36 ›› Issue (9) : 814-817.

PDF(967 KB)
PDF(967 KB)
武警医学 ›› 2025, Vol. 36 ›› Issue (9) : 814-817.
综述

铁死亡参与急性胰腺炎发病机制的研究进展

  • 高庆红1,2, 许威2, 夏时海2
作者信息 +
文章历史 +

摘要

急性胰腺炎(AP)是一种常见的急性消化系统疾病,严重威胁患者生命健康。近年的研究发现,铁死亡是一种以铁离子过载和磷脂过氧化为核心的程序化细胞死亡方式,在AP的发生、进展及多器官损伤中起关键作用。最新研究显示,通过干预铁死亡相关靶点可显著改善动物模型的炎症反应和器官功能,为AP的靶向治疗提供了新思路。本文综述了铁死亡的分子机制及其在AP发病机制中的作用,并围绕铁死亡关键环节,探讨相关的干预策略与潜在治疗靶点,以期为AP治疗提供新的参考依据。

关键词

铁死亡 / 急性胰腺炎 / 铁死亡机制 / 急性胰腺炎治疗

引用本文

导出引用
高庆红, 许威, 夏时海. 铁死亡参与急性胰腺炎发病机制的研究进展[J]. 武警医学. 2025, 36(9): 814-817
中图分类号: R576   

参考文献

[1] Liu K, Liu J, Zou B, et al. Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice[J]. Cell Mol Gastroenterol Hepatol, 2022, 13(2):483-500.
[2] Mederos M A, Reber H A, Girgis M D. Acute Pancreatitis: a Review[J]. JAMA, 2021, 325(4):382-390.
[3] Lee P J, Papachristou G I. New insights into acute pancreatitis[J]. Nat Rev Gastroenterol Hepatol, 2019, 16(8):479-496.
[4] Li J, Cao F, Yin H L, et al. Ferroptosis: past, present and future[J]. Cell Death Dis, 2020, 11(2):88.
[5] Jiang X, Stockwell B R, Conrad M. Ferroptosis: mechanisms, biology and role in disease[J]. Nat Rev Mol Cell Biol, 2021, 22(4):266-282.
[6] Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications[J]. Cell Res, 2021, 31(2):107-125.
[7] Li H, Lin Y, Zhang L, et al. Ferroptosis and its emerging roles in acute pancreatitis[J]. Chin Med J (Engl). 2022, 135(17):2026-2034.
[8] Dixon S J, Lemberg K M, Lamprecht M R, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5):1060-1072.
[9] Li J, Jia Y C, Ding Y X, et al. The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks[J]. Int J Biol Sci, 2023, 19(9):2756-2771.
[10] Dixon S J, Stockwell B R. The role of iron and reactive oxygen species in cell death[J]. Nat Chem Biol, 2014, 10(1):9-17.
[11] Chen X, Li J, Kang R, et al. Ferroptosis: machinery and regulation[J]. Autophagy, 2021, 17(9):2054-2081.
[12] Du S, Shi H, Xiong L, et al. Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy[J]. Front Endocrinol (Lausanne), 2022, 13:1011669.
[13] Xu X, Xu X D, Ma M Q, et al. The mechanisms of ferroptosis and its role in atherosclerosis[J]. Biomed Pharmacother, 2024, 171:116112.
[14] Wang G J, Gao C F, Wei D, et al. Acute pancreatitis: etiology and common pathogenesis[J]. World J Gastroenterol, 2009, 15(12):1427-30.
[15] Deng Y, Jiang T, Li J, et al. Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis[J]. iScience, 2023, 26(10):107774.
[16] Mariia L, Peggy S, Renwar N, et al. Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells[J]. J Pathol, 2017, 241(1):104-114.
[17] Siriviriyakul P, Sriko J, Somanawat K, et al. Genistein attenuated oxidative stress, inflammation, and apoptosis in L-arginine induced acute pancreatitis in mice[J]. BMC Complement Med Ther, 2022, 22(1):208.
[18] Zhang H, Zhang G, Xiang F, et al. Clinical efficacy of ilaprazole combined with somatostatin on severe acute pancreatitis and the effects on oxidative stress and inflammatory response[J]. Pak J Pharm Sci, 2024, 37(4):849-853.
[19] Cai W, Li Z, Wang W, et al. Resveratrol in animal models of pancreatitis and pancreatic cancer: a systematic review with machine learning[J]. Phytomedicine, 2025, 139156538.
[20] Shin D, Kim E H, Lee J, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer[J]. Free Radic Biol Med, 2018, 129:454-462.
[21] Almutary H K, Zaghloul S M, Nader A M, et al. Mechanistic insights into the protective potential of ambrisentan against L-arginine induced acute pancreatitis and multiorgan damage (role of NRF2/HO-1 and TXNIP/NLRP3 pathways)[J]. Biomed Pharmacother, 2025, 187118119.
[22] Liu X, Zhu Q, Zhang M, et al. Isoliquiritigenin ameliorates acute pancreatitis in mice via inhibition of oxidative stress and modulation of the Nrf2/HO-1 pathway[J]. Oxid Med Cell Longev, 2018, 2018:7161592.
[23] Liu J, Kang R, Tang D. Signaling pathways and defense mechanisms of ferroptosis[J]. FEBS J, 2022, 89(22):7038-7050.
[24] Yang Z, Su W, Wei X, et al. HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1[J]. Cell Rep, 2023, 42(8):112945.
[25] Yue F, Shi Y, Wu S, et al. Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD[J]. iScience, 2023, 26(12):108560.
[26] Chen X, Song X, Li J, et al. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis[J]. Autophagy, 2023, 19(1):54-74.
[27] Koonyosying P, Kongkarnka S, Uthaipibull C, et al. Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation[J]. Biomed Pharmacother, 2018, 108:1694-1702.
[28] Li H, Wu D, Zhang H, et al. Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis[J]. BMC Gastroenterol, 2024, 24(1):245.
[29] Xiang X, Xu M, Liu L, et al. Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats[J]. Sci Rep, 2024, 14(1):9548.
[30] Vlavcheski F, O’Neill EJ, Gagacev F, et al. Effects of berberine against pancreatitis and pancreatic cancer[J]. Molecules, 2022, 27(23):8630.
[31] Chen W, Yuan C, Lu Y, et al. Tanshinone IIA protects against acute pancreatitis in mice by inhibiting oxidative stress via the Nrf2/ROS pathway[J]. Oxid Med Cell Longev, 2020, 2020:5390482.
[32] Shan Y, Li J, Zhu A, et al. Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO-1-mediated ferroptosis pathway[J]. Int J Mol Med, 2022, 50(1):1-10.
[33] Zheng Y, Sun W, Shan C, et al. β-hydroxybutyrate inhibits ferroptosis-mediated pancreatic damage in acute liver failure through the increase of H3K9bhb[J]. Cell Rep, 2022, 41(12):111847.
[34] Chen F, Su M, Han D, et al. METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1[J]. Int Immunopharmacol, 2024, 128:111495.

基金

天津市卫生健康科技项目(TJWJ2023QN100)

PDF(967 KB)

Accesses

Citation

Detail

段落导航
相关文章

/