目的 探讨强直性脊柱炎(AS)患者免疫功能、凝血功能指标与脊柱活动度的相关性。方法 选取2019-11至2024-11于武警特色医学中心就诊的AS患者150例,根据AS疾病活动指数(BASDAI)分为活动期组和稳定期组,比较两组凝血与纤溶活性相关指标、血小板计数(PLT)、红细胞沉降率(ESR)、C反应蛋白(CRP)、血栓形成相关因子、Th17/Treg及相关因子、氧化应激指标水平,分析BASDAI、巴氏功能指数(BASFI)与上述指标的相关性。结果 与稳定期组比较,活动期组的纤维蛋白原(FIB)、D-二聚体、PLT、纤维蛋白降解产物(FDP)、血栓素A2(TXA2)、纤溶酶原激活剂抑制剂(PAI)、ESR、CRP、Th17、Th17/Treg、白介素(IL)-17、IL-23、丙二醛水平更高,而活化部分凝血活酶时间(APTT)、前列环素(PGI2)、Treg、IL-10、转化生长因子-β(TGF-β)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平更低(P＜0.05);相关性分析结果显示,AS患者BASDAI、BASFI指数与D-二聚体、PLT、FDP、TXA2、PAI、ESR、CRP、Th17、Th17/Treg、IL-17、IL-23、MDA水平呈正相关,而与APTT、PGI2、Treg、IL-10、TGF-β、SOD、CAT呈负相关(P＜0.05)。结论 AS患者凝血功能、免疫功能和氧化应激指标与病情活动和脊柱活动度存在密切联系。
Abstract
Objective To explore the correlation between immune function, coagulation function indicators and spinal mobility in patients with ankylosing spondylitis (AS). Methods A total of 150 AS patients who visited Characteristics Medical Center of Chinese People’s Armed Police Force from November 2019 to November 2024 were selected and divided into an active stage group and a stable stage group according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The levels of indicators related with coagulation and fibrinolytic activity, platelet count (PLT), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), factors related with thrombosis, Th17/Treg and related factors, and oxidative stress indicators were compared between the two groups. The correlations between BASDAI, Bath Ankylosing spondylitis Functional Index (BASFI) and the above indicators was analyzed. Results Compared with the stable stage group, the levels of fibrinogen (FIB), D-dimer, PLT, fibrin degradation products (FDP), thrombin A2 (TXA2), plasminogen activator inhibitor (PAI), ESR, CRP, Th17, Th17/Treg, interleukin (IL)-17, IL-23 and malondialdehyde (MDA)were higher in the active stage group, while the levels of activated partial thromboplastin time (APTT), prostacyclin (PGI2), Treg, IL-10, transforming growth factor -β (TGF-β), superoxide dismutase (SOD), and catalase (CAT) were lower (P<0.05); Correlation analysis showed that BASDAI and BASFI in AS patients were positively correlated with D-dimer, PLT, FDP, TXA2, PAI, ESR, CRP, Th17, Th17/Treg, IL-17, IL-23, and MDA, and negatively correlated with APTT, PGI2, Treg, IL-10, TGF-β, SOD and CAT (P<0.05). Conclusions The coagulation function, immune function and oxidative stress indicators in AS patients are closely related with the disease activity and spinal mobility.
关键词
强直性脊柱炎 /
凝血功能 /
免疫 /
脊柱活动度 /
相关性
Key words
ankylosing spondylitis /
coagulation function /
immunity /
spinal mobility /
correlation
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